Table 1.

Functional changes in whole cell CFTR in response to decaging pulse

CFTR variantFold change (relative to 1)Kinetics (τ, seconds)n
 Value SD Value SD  
WT 0.995 0.010 N/A N/A 
S700(cagedser) 1.111 0.099 17.3 2.4 
S737(cagedser) 2.542 0.978 38.7 19.2 
S768(cagedser) 0.934 0.034 12.9 2.0 
S795(cagedser) 8.385 4.664 t1 = 11.4
t2 = 155.6 
t1 = 1.1
t2 = 108.2 
S813(cagedser) 12.055 0.893 161.0 68.8 
CFTR variantFold change (relative to 1)Kinetics (τ, seconds)n
 Value SD Value SD  
WT 0.995 0.010 N/A N/A 
S700(cagedser) 1.111 0.099 17.3 2.4 
S737(cagedser) 2.542 0.978 38.7 19.2 
S768(cagedser) 0.934 0.034 12.9 2.0 
S795(cagedser) 8.385 4.664 t1 = 11.4
t2 = 155.6 
t1 = 1.1
t2 = 108.2 
S813(cagedser) 12.055 0.893 161.0 68.8 

Bolded values are P < 0.05 by Student’s t test (unpaired) compared to that of S813(cagedser).

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