Table 1. AP waveform parameter... | Rockefeller University Press

Table 1.

AP waveform parameter definitions

Waveform parameter	Abbreviation	Definition
Firing rate	FR (AP/min)	Number of APs fired per minute
Diastolic duration	DD (ms)^{^a}	Time from maximum diastolic potential until the threshold potential
Early diastolic duration	EDD (ms)	Time from maximum diastolic potential until the rate of depolarization deviates from a linear fit
Late diastolic duration	LDD (ms)	Time from when the rate of diastolic depolarization deviates from a linear fit until threshold
Action potential duration	APD (ms)	Time interval between the threshold potential during AP upstroke and the subsequent maximum diastolic potential
Action potential duration at 50% repolarization	APD₅₀ (ms)	Time interval for 50% repolarization
Action potential duration at 90% repolarization	APD₉₀ (ms)^{^a}	Time interval for 90% repolarization
Late action potential duration	LAPD (ms)^{^a}	Time from when the threshold potential is reached during the repolarization phase until the subsequent maximum diastolic potential
Maximum diastolic potential	MDP (mV)^{^a}	Most negative membrane potential during diastolic depolarization phase
Threshold	THR (mV)^{^a}	Time at which the upstroke velocity reaches 0.5 mV/ms
Peak potential	PP (mV)^{^a}	Most positive potential during the AP upstroke
Action potential amplitude	APA (mV)	Difference between maximum diastolic potential and peak potential
Diastolic depolarization rate	DDR (mV/ms)^{^a}	Rate of the membrane potential change at the end of the early diastolic duration
Maximum upstroke velocity	MUV (mV/ms)^{^a}	Maximum of the derivative between maximum diastolic potential and peak potential
Maximum repolarization rate	MRR (mV/ms)^{^a}	Minimum of the derivative between peak potential and the subsequent maximum diastolic potential

Waveform parameter	Abbreviation	Definition
Firing rate	FR (AP/min)	Number of APs fired per minute
Diastolic duration	DD (ms)^{^a}	Time from maximum diastolic potential until the threshold potential
Early diastolic duration	EDD (ms)	Time from maximum diastolic potential until the rate of depolarization deviates from a linear fit
Late diastolic duration	LDD (ms)	Time from when the rate of diastolic depolarization deviates from a linear fit until threshold
Action potential duration	APD (ms)	Time interval between the threshold potential during AP upstroke and the subsequent maximum diastolic potential
Action potential duration at 50% repolarization	APD₅₀ (ms)	Time interval for 50% repolarization
Action potential duration at 90% repolarization	APD₉₀ (ms)^{^a}	Time interval for 90% repolarization
Late action potential duration	LAPD (ms)^{^a}	Time from when the threshold potential is reached during the repolarization phase until the subsequent maximum diastolic potential
Maximum diastolic potential	MDP (mV)^{^a}	Most negative membrane potential during diastolic depolarization phase
Threshold	THR (mV)^{^a}	Time at which the upstroke velocity reaches 0.5 mV/ms
Peak potential	PP (mV)^{^a}	Most positive potential during the AP upstroke
Action potential amplitude	APA (mV)	Difference between maximum diastolic potential and peak potential
Diastolic depolarization rate	DDR (mV/ms)^{^a}	Rate of the membrane potential change at the end of the early diastolic duration
Maximum upstroke velocity	MUV (mV/ms)^{^a}	Maximum of the derivative between maximum diastolic potential and peak potential
Maximum repolarization rate	MRR (mV/ms)^{^a}	Minimum of the derivative between peak potential and the subsequent maximum diastolic potential

Denotes AP waveform parameters used in the machine learning predictions of firing rate.