Correlation between patient clinical outcome and NK cell infiltration or fitness
| Indication . | Results . | Author . |
|---|---|---|
| Breast cancer | Trastuzumab-responsive tumors present a trend toward increased NK cell infiltration compared to non-responsive tumors | Arnould et al., 2006 |
| Tumor-infiltrating NK cells were significantly associated with pathologic complete response and prolonged disease-free survival | Muntasell et al., 2019 | |
| NK cell infiltration correlates with improved prognosis | Denkert et al., 2018 | |
| Cervical cancer | Downregulation of NKp46, NKp30, and NKG2D on NK cells were correlated with tumor progression | Garcia-Iglesias et al., 2009 |
| Colorectal cancer | Higher NK cell infiltration correlated with better overall survival | Foroutan et al., 2021 |
| Higher numbers of pre-operative NK cells correlated with reduced risk of recurrence | Tartter, 1987 | |
| NK cell activity is a strong prognostic factor for patients with metastatic colorectal cancer | Liljefors et al., 2003 | |
| Preoperative peripheral NK cell activity has a significant prognostic value in curatively operated colon cancer | Kondo et al., 2003 | |
| Gastric cancer | The density of the NK cell infiltration in tumor foci after imatinib mesylate treatment independently predicted PFS | Rusakiewicz et al., 2013 |
| NK cell abundance is associated with the response to sorafinib, and higher NK cell abundance may prolong overall survival | Wu et al., 2020 | |
| NK cell IFN-γ production after 2 mo of treatment is an independent predictor of long-term survival in advanced gastrointestinal stromal tumors treated with imatinib | Ménard et al., 2009 | |
| Patients with high circulating NK cell counts had a better overall survival | Pernot et al., 2020 | |
| Head and neck cancer | CD8+ T cell infiltration and CD56dim NK cell infiltration each correlated with superior survival in head and neck squamous cell carcinoma | Mandal et al., 2016 |
| Peripheral NK cell cytotoxicity was inversely related to subsequent death with disease progression | Schantz et al., 1991 | |
| Patients with elevated NK activity had an improved disease-free survival | Schantz et al., 1986 | |
| Diminished NK cell function was associated with an increased risk of death from uncontrolled regional and distant metastases | Schantz et al., 1989 | |
| Hepatocellular carcinoma | Patients with lower NK cell infiltration had shorter overall survival | Zhu et al., 2009 |
| Recurrence-free survival of patients with tumors lacking the expression of the NKG2D-ligand ULBP1 was significantly shorter | Kamimura et al., 2012 | |
| Lung cancer | High NK cell infiltration correlated with better outcome | Federico et al., 2021 |
| Increased NK, DC, T CD8+, and B cell infiltration correlated with improved outcome | Soo et al., 2018 | |
| Increased NK cell infiltration correlated with better survival | Villagas et al., 2002 | |
| Melanoma | Higher ratio of CD56dim/CD56bright in tumor-infiltrated lymph nodes correlated with improved survival | Ali et al., 2014 |
| Higher NK cell infiltration in tumors correlated with improved survival | Cursons et al., 2019 | |
| Higher NK cell infiltration in tumors correlated with improved survival and predicted PD-1 responsiveness | Barry et al., 2018 | |
| NKp46 expression predicted melanoma outcome | Messaoudene et al., 2016 | |
| Neuroblastoma | Increased level of tumor-infiltrating NK cells was associated with better prognosis | Semeraro et al., 2015a |
| Patients with high-risk neuroblastoma in remission after induction chemotherapy had a higher risk of relapse if their circulating and bone marrow NK cells express the immunosuppressive NKp30 C isoform | Semeraro et al., 2015b | |
| Prostate cancer | NKp46 expression by circulating NK cells in prostate metastatic patients inversely correlated with the levels of prostate-specific antigen | Pasero et al., 2016 |
| Hematologic malignancies | Higher number of NK cells in the bone marrow at diagnosis positively correlated with the response to treatment and the frequency of remission | Mizia-Malarz and Sobol-Milejska, 2019 |
| The presence of active cytotoxic NK cells had a positive effect on the disease control after chemotherapy | Sullivan et al., 2014 | |
| Higher NK cell numbers correlated with reduced severity | Palmer et al., 2008 | |
| Higher NK cell numbers correlated with increased survival | Gonzalez-Rodriguez et al., 2010 | |
| Higher number of circulating NK cells was associated with better prognosis and overall survival | Plonquet et al., 2007 | |
| Higher NK cell infiltration correlated with favorable prognosis | Álvaro-Naranjo et al., 2005 | |
| Multiple cancer types | High NK cell activity in peripheral blood was associated with reduced risk of cancer, whereas low activity was associated with increased risk of cancer | Imai et al., 2000 |
| Indication . | Results . | Author . |
|---|---|---|
| Breast cancer | Trastuzumab-responsive tumors present a trend toward increased NK cell infiltration compared to non-responsive tumors | Arnould et al., 2006 |
| Tumor-infiltrating NK cells were significantly associated with pathologic complete response and prolonged disease-free survival | Muntasell et al., 2019 | |
| NK cell infiltration correlates with improved prognosis | Denkert et al., 2018 | |
| Cervical cancer | Downregulation of NKp46, NKp30, and NKG2D on NK cells were correlated with tumor progression | Garcia-Iglesias et al., 2009 |
| Colorectal cancer | Higher NK cell infiltration correlated with better overall survival | Foroutan et al., 2021 |
| Higher numbers of pre-operative NK cells correlated with reduced risk of recurrence | Tartter, 1987 | |
| NK cell activity is a strong prognostic factor for patients with metastatic colorectal cancer | Liljefors et al., 2003 | |
| Preoperative peripheral NK cell activity has a significant prognostic value in curatively operated colon cancer | Kondo et al., 2003 | |
| Gastric cancer | The density of the NK cell infiltration in tumor foci after imatinib mesylate treatment independently predicted PFS | Rusakiewicz et al., 2013 |
| NK cell abundance is associated with the response to sorafinib, and higher NK cell abundance may prolong overall survival | Wu et al., 2020 | |
| NK cell IFN-γ production after 2 mo of treatment is an independent predictor of long-term survival in advanced gastrointestinal stromal tumors treated with imatinib | Ménard et al., 2009 | |
| Patients with high circulating NK cell counts had a better overall survival | Pernot et al., 2020 | |
| Head and neck cancer | CD8+ T cell infiltration and CD56dim NK cell infiltration each correlated with superior survival in head and neck squamous cell carcinoma | Mandal et al., 2016 |
| Peripheral NK cell cytotoxicity was inversely related to subsequent death with disease progression | Schantz et al., 1991 | |
| Patients with elevated NK activity had an improved disease-free survival | Schantz et al., 1986 | |
| Diminished NK cell function was associated with an increased risk of death from uncontrolled regional and distant metastases | Schantz et al., 1989 | |
| Hepatocellular carcinoma | Patients with lower NK cell infiltration had shorter overall survival | Zhu et al., 2009 |
| Recurrence-free survival of patients with tumors lacking the expression of the NKG2D-ligand ULBP1 was significantly shorter | Kamimura et al., 2012 | |
| Lung cancer | High NK cell infiltration correlated with better outcome | Federico et al., 2021 |
| Increased NK, DC, T CD8+, and B cell infiltration correlated with improved outcome | Soo et al., 2018 | |
| Increased NK cell infiltration correlated with better survival | Villagas et al., 2002 | |
| Melanoma | Higher ratio of CD56dim/CD56bright in tumor-infiltrated lymph nodes correlated with improved survival | Ali et al., 2014 |
| Higher NK cell infiltration in tumors correlated with improved survival | Cursons et al., 2019 | |
| Higher NK cell infiltration in tumors correlated with improved survival and predicted PD-1 responsiveness | Barry et al., 2018 | |
| NKp46 expression predicted melanoma outcome | Messaoudene et al., 2016 | |
| Neuroblastoma | Increased level of tumor-infiltrating NK cells was associated with better prognosis | Semeraro et al., 2015a |
| Patients with high-risk neuroblastoma in remission after induction chemotherapy had a higher risk of relapse if their circulating and bone marrow NK cells express the immunosuppressive NKp30 C isoform | Semeraro et al., 2015b | |
| Prostate cancer | NKp46 expression by circulating NK cells in prostate metastatic patients inversely correlated with the levels of prostate-specific antigen | Pasero et al., 2016 |
| Hematologic malignancies | Higher number of NK cells in the bone marrow at diagnosis positively correlated with the response to treatment and the frequency of remission | Mizia-Malarz and Sobol-Milejska, 2019 |
| The presence of active cytotoxic NK cells had a positive effect on the disease control after chemotherapy | Sullivan et al., 2014 | |
| Higher NK cell numbers correlated with reduced severity | Palmer et al., 2008 | |
| Higher NK cell numbers correlated with increased survival | Gonzalez-Rodriguez et al., 2010 | |
| Higher number of circulating NK cells was associated with better prognosis and overall survival | Plonquet et al., 2007 | |
| Higher NK cell infiltration correlated with favorable prognosis | Álvaro-Naranjo et al., 2005 | |
| Multiple cancer types | High NK cell activity in peripheral blood was associated with reduced risk of cancer, whereas low activity was associated with increased risk of cancer | Imai et al., 2000 |