Patients with auto-Abs neutralizing type I IFNs and influenza pneumonia
| Patient . | Auto-Abs . | Gender . | Age (yr) . | Residence . | Influenza pneumonia severity . | Viral strain . | Vaccinated . | Clinical history . | Outcome . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-α (10 ng/ml) . | IFN-α (100 pg/ml) . | IFN-ω (10 ng/ml) . | IFN-ω (100 pg/ml) . | IFN-β (10 ng/ml) . | |||||||||
| P1 | + | + | + | + | − | M | 73 | Greece | Bilateral lung infiltrates, noninvasive mechanical ventilation | IAV (H3) | NA | COPD, sleep breathing disorder, cardiovascular disease, heart failure, hypertension, dyslipidemia | Survived |
| P2 | + | NA | + | NA | − | F | 67 | Belgium | Admitted to ICU, noninvasive ventilation for 5 d | IAV | NA | Rheumatoid arthritis under methotrexate, local nasal corticosteroids | Survived |
| P3 | + | + | + | + | − | M | 28 | Belgium | Admitted to ICU, invasive ventilation for 10 d | IAV | NA | Hypothyroidism, GI reflux, urolithiasis, limited metabolic syndrome (new-observation HbA1c 6.2%) | Survived |
| P4 | + | + | + | + | − | F | 56 | Spain | ARDS | IAV (H1N1) | No | NA | |
| P5 | + | + | + | + | − | M | 62 | Spain | ARDS | NA | NA | NA | |
| P6 | + | + | + | + | − | M | 62 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P7 | + | + | − | + | − | M | 55 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P8 | + | + | − | − | − | M | 70 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P9 | + | + | − | − | − | M | 40 | France | Admitted to ICU, ARDS, intubated, ECMO | IAV (H1N1) | NA | Meningitis at 3 mo of age | Survived |
| P10 | − | + | − | + | − | M | 6 | Israel | Admitted to ICU, ARDS | IAV (H1N1) | No | Diagnosed with mitochondrial complex I deficiency (family history showed brother died of RSV infection at 3 mo of age) | Survived |
| P11 | − | + | − | − | − | F | 48 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P12 | − | + | − | − | − | M | 39 | France | Admitted to ICU, intubated, ECMO | IAV | NA | NA | |
| P13 | − | + | − | − | − | M | 70 | France | Admitted to ICU | IAV | NA | Survived | |
| P14 | + | + | + | + | + | M | 55 | Chile | Hospitalized with oxygen therapy | IAV | No | Dyslipidemia | Survived |
| P15 | + | + | + | + | + | M | 6 | France | Intubated for hypoxemia influenza pneumonia, with secondary bacterial infection, intubated | IAV (H1N1) | NA | Failure to thrive, ulcerative digestive lesions due to disseminated CMV infection | Deceased |
| P16 | + | + | + | + | + | F | 1.3 | Belgium | ARDS, intubated | IAV (H1N1) | No | Diarrhea after oral rotavirus vaccine and skin eruption after MMRV vaccine, autoimmune hemolytic anemia, autoimmune pancreatitis | Deceased |
| P17 | + | + | + | + | − | M | 43 | Chile | Admitted to ICU, intubated | IAV (H1) | No | Chikungunya (2015) in Colombia | Survived |
| P18 | + | + | + | + | − | M | 64 | Chile | Hospitalized with oxygen therapy | IAV (H3) | No | Dyslipidemia, infrarenal abdominal aortic aneurysm | Survived |
| P19 | + | + | + | + | − | M | 81 | Chile | Hospitalized | IAV (H3) | Yes | Survived | |
| P20 | + | + | + | + | − | M | 83 | Spain | Hospitalized | IAV (H3) | Yes | Diabetes | Survived |
| P21 | + | + | − | + | − | F | 85 | Chile | Admitted to ICU, intubated | IAV (H1) | No | Obesity, arterial hypertension, asthma | Survived |
| P22 | + | + | − | − | − | F | 91 | Spain | Hospitalized with oxygen therapy | IAV (H1N1) | No | Asthma, heart disease, diabetes | Survived |
| P23 | − | − | + | + | − | M | 8 | Taiwan | Admitted to ICU with oxygen therapy | IAV | NA | Sister died of encephalitis due to IAV (H1N1) | Survived |
| Patient . | Auto-Abs . | Gender . | Age (yr) . | Residence . | Influenza pneumonia severity . | Viral strain . | Vaccinated . | Clinical history . | Outcome . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-α (10 ng/ml) . | IFN-α (100 pg/ml) . | IFN-ω (10 ng/ml) . | IFN-ω (100 pg/ml) . | IFN-β (10 ng/ml) . | |||||||||
| P1 | + | + | + | + | − | M | 73 | Greece | Bilateral lung infiltrates, noninvasive mechanical ventilation | IAV (H3) | NA | COPD, sleep breathing disorder, cardiovascular disease, heart failure, hypertension, dyslipidemia | Survived |
| P2 | + | NA | + | NA | − | F | 67 | Belgium | Admitted to ICU, noninvasive ventilation for 5 d | IAV | NA | Rheumatoid arthritis under methotrexate, local nasal corticosteroids | Survived |
| P3 | + | + | + | + | − | M | 28 | Belgium | Admitted to ICU, invasive ventilation for 10 d | IAV | NA | Hypothyroidism, GI reflux, urolithiasis, limited metabolic syndrome (new-observation HbA1c 6.2%) | Survived |
| P4 | + | + | + | + | − | F | 56 | Spain | ARDS | IAV (H1N1) | No | NA | |
| P5 | + | + | + | + | − | M | 62 | Spain | ARDS | NA | NA | NA | |
| P6 | + | + | + | + | − | M | 62 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P7 | + | + | − | + | − | M | 55 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P8 | + | + | − | − | − | M | 70 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P9 | + | + | − | − | − | M | 40 | France | Admitted to ICU, ARDS, intubated, ECMO | IAV (H1N1) | NA | Meningitis at 3 mo of age | Survived |
| P10 | − | + | − | + | − | M | 6 | Israel | Admitted to ICU, ARDS | IAV (H1N1) | No | Diagnosed with mitochondrial complex I deficiency (family history showed brother died of RSV infection at 3 mo of age) | Survived |
| P11 | − | + | − | − | − | F | 48 | France | Admitted to ICU, intubated | IAV | NA | Survived | |
| P12 | − | + | − | − | − | M | 39 | France | Admitted to ICU, intubated, ECMO | IAV | NA | NA | |
| P13 | − | + | − | − | − | M | 70 | France | Admitted to ICU | IAV | NA | Survived | |
| P14 | + | + | + | + | + | M | 55 | Chile | Hospitalized with oxygen therapy | IAV | No | Dyslipidemia | Survived |
| P15 | + | + | + | + | + | M | 6 | France | Intubated for hypoxemia influenza pneumonia, with secondary bacterial infection, intubated | IAV (H1N1) | NA | Failure to thrive, ulcerative digestive lesions due to disseminated CMV infection | Deceased |
| P16 | + | + | + | + | + | F | 1.3 | Belgium | ARDS, intubated | IAV (H1N1) | No | Diarrhea after oral rotavirus vaccine and skin eruption after MMRV vaccine, autoimmune hemolytic anemia, autoimmune pancreatitis | Deceased |
| P17 | + | + | + | + | − | M | 43 | Chile | Admitted to ICU, intubated | IAV (H1) | No | Chikungunya (2015) in Colombia | Survived |
| P18 | + | + | + | + | − | M | 64 | Chile | Hospitalized with oxygen therapy | IAV (H3) | No | Dyslipidemia, infrarenal abdominal aortic aneurysm | Survived |
| P19 | + | + | + | + | − | M | 81 | Chile | Hospitalized | IAV (H3) | Yes | Survived | |
| P20 | + | + | + | + | − | M | 83 | Spain | Hospitalized | IAV (H3) | Yes | Diabetes | Survived |
| P21 | + | + | − | + | − | F | 85 | Chile | Admitted to ICU, intubated | IAV (H1) | No | Obesity, arterial hypertension, asthma | Survived |
| P22 | + | + | − | − | − | F | 91 | Spain | Hospitalized with oxygen therapy | IAV (H1N1) | No | Asthma, heart disease, diabetes | Survived |
| P23 | − | − | + | + | − | M | 8 | Taiwan | Admitted to ICU with oxygen therapy | IAV | NA | Sister died of encephalitis due to IAV (H1N1) | Survived |
+, positive; −, negative; COPD, Chronic obstructive pulmonary disease; F, female; GI, gastrointestinal; M, male; NA, data not available; RSV, respiratory syncytial virus.