Table 1. Molecular identification of... | Rockefeller University Press

Table 1.

Molecular identification of renal transport proteins implicated in Na⁺ and K⁺ homeostasis

Segment	Transporter	Gene	Pole	Function	Ref.
PT	NHE3	Slc9a3	Apical	Na⁺ reabsorption	Bobulescu and Moe (2009)
	Kir4.2/5.1	Kcnj15/16	Basolateral	K⁺ recycling	Lin et al. (2022)
	TASK-2	Kcnk5	Basolateral	K⁺ recycling	Warth et al. (2004)
TALH	NKCC2	Slc12a1	Apical	K⁺, Cl⁻ reabsorption	Bazua-Valenti et al. (2016)
	ROMK	Kcnj1	Apical	K⁺ secretion	Welling and Ho (2009)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ reabsorption	Wang and Lin (2022)
	KCC4	Slc12a7	Basolateral	K⁺, Cl⁻ reabsorption	Bazua-Valenti et al. (2016)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Teulon et al. (2018)
DCT	NCC	Slc12a3	Apical	Na⁺, Cl⁻ reabsorption	Hoorn et al. (2020)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ recycling	Wang and Lin (2022)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Teulon et al. (2018)
CD/PC	ENaC	Scnn1	Apical	Na⁺ reabsorption	Garty and Palmer (1997)
	ROMK	Kcnj1	Apical	K⁺ secretion	Welling and Ho (2009)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ recycling	Wang and Lin (2022)
CD/IC	pendrin	Slc26a4	Apical	Cl⁻ reabsorption	Wall et al. (2020)
	AE1	Slc4a1	Basolateral	Cl⁻ recycling	Wall et al. (2020)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Wall et al. (2020)
	BK	Kcnma1	Apical	K⁺ secretion	Carrisoza-Gaytan et al. (2016)

Segment	Transporter	Gene	Pole	Function	Ref.
PT	NHE3	Slc9a3	Apical	Na⁺ reabsorption	Bobulescu and Moe (2009)
	Kir4.2/5.1	Kcnj15/16	Basolateral	K⁺ recycling	Lin et al. (2022)
	TASK-2	Kcnk5	Basolateral	K⁺ recycling	Warth et al. (2004)
TALH	NKCC2	Slc12a1	Apical	K⁺, Cl⁻ reabsorption	Bazua-Valenti et al. (2016)
	ROMK	Kcnj1	Apical	K⁺ secretion	Welling and Ho (2009)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ reabsorption	Wang and Lin (2022)
	KCC4	Slc12a7	Basolateral	K⁺, Cl⁻ reabsorption	Bazua-Valenti et al. (2016)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Teulon et al. (2018)
DCT	NCC	Slc12a3	Apical	Na⁺, Cl⁻ reabsorption	Hoorn et al. (2020)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ recycling	Wang and Lin (2022)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Teulon et al. (2018)
CD/PC	ENaC	Scnn1	Apical	Na⁺ reabsorption	Garty and Palmer (1997)
	ROMK	Kcnj1	Apical	K⁺ secretion	Welling and Ho (2009)
	Kir4.1/5.1	Kcnj10/16	Basolateral	K⁺ recycling	Wang and Lin (2022)
CD/IC	pendrin	Slc26a4	Apical	Cl⁻ reabsorption	Wall et al. (2020)
	AE1	Slc4a1	Basolateral	Cl⁻ recycling	Wall et al. (2020)
	CLCKb	Clcnkb	Basolateral	Cl⁻ reabsorption	Wall et al. (2020)
	BK	Kcnma1	Apical	K⁺ secretion	Carrisoza-Gaytan et al. (2016)

CD/PC, principal cells of collecting duct; CD/IC, intercalated cells of collecting duct.