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Table 1.
Summary of the correlation of expression of several endothelial- and epithelial-specific factors with physiological markers of COPD (% FEV1, % DLCO, and % emphysema)
% FEV1 adjusted for age, sex, library% DLCO adjusted for age, sex, library% Emphysema adjusted for age, sex, library
R2P valueaR2P valueaR2P valuea
Endothelial markers 
KDR 0.11 5.5 × 10−9 0.136 1.01 × 10−10 0.078 4.74 × 10−5 
VEGFA 0.09 4.7 × 10−9 0.152 3.9 × 10−12 0.014 0.035 
ICAM2 0.022 0.0031 0.06 6.17 × 10−6 0.009 0.08 
TEK 0.019 0.013 0.06 2.46 × 10−5 0.01 0.023 
TIE1 0.047 5.7 × 10−6 0.095 1.7 × 10−8 0.051 5.8 × 10−5 
Epithelial cell markers 
CDH1 0.007 0.1 0.018 0.0167 0.0016 0.24 
SFTPD 2.12 × 10−6 0.8 0.023 0.0049 0.0018 0.346 
AQP5 0.011 0.02 1.6 × 10−5 0.97 0.0027 0.153 
SFTPC 0.0078 0.149 0.03 0.003 0.0045 0.3 
% FEV1 adjusted for age, sex, library% DLCO adjusted for age, sex, library% Emphysema adjusted for age, sex, library
R2P valueaR2P valueaR2P valuea
Endothelial markers 
KDR 0.11 5.5 × 10−9 0.136 1.01 × 10−10 0.078 4.74 × 10−5 
VEGFA 0.09 4.7 × 10−9 0.152 3.9 × 10−12 0.014 0.035 
ICAM2 0.022 0.0031 0.06 6.17 × 10−6 0.009 0.08 
TEK 0.019 0.013 0.06 2.46 × 10−5 0.01 0.023 
TIE1 0.047 5.7 × 10−6 0.095 1.7 × 10−8 0.051 5.8 × 10−5 
Epithelial cell markers 
CDH1 0.007 0.1 0.018 0.0167 0.0016 0.24 
SFTPD 2.12 × 10−6 0.8 0.023 0.0049 0.0018 0.346 
AQP5 0.011 0.02 1.6 × 10−5 0.97 0.0027 0.153 
SFTPC 0.0078 0.149 0.03 0.003 0.0045 0.3 
a

Generalized linear model Wald statistics were used to assess the significance of coefficients in relevant models.

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