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Table 3.
Unloaded single-molecule motility properties
KIF1A motorVelocity (μm/s)aRun length (μm)bLanding rate (events⋅min−1⋅nM−1⋅μm−1)c
KIF1A(1–393)C 2.1 ± 0.1 16.7 (10.2, 27.2) 10.7 ± 0.6 
KIF1A(1–393)-V8MC 1.3 ± 0.1e 4.1 (2.1, 7.0)f 1.5 ± 0.1e 
KIF1A(1–393)-Y89DC 1.7 ± 0.1e 2.0 (1.2, 3.5)f 2.8 ± 0.1e 
KIF1A(1–393)-WTE 2.5 ± 0.2 12.2 (6.7, 18.4) ND 
KIF1A(1–393)-V8ME 1.3 ± 0.1 7.3 (4.4, 12.2) ND 
KIF1A(1–393)-Y89DE 1.7 ± 0.2 6.3 (4.0, 10.7) ND 
KIF1A(FL)C 0.3 ± 0.1 2.8 (1.5, 3.7) 2.0 ± 0.2 
KIF1A(FLAct)C 1.9 ± 0.1 9.3 (4.7, 12.7) 2.8 ± 0.6 
KIF1A(FLAct)-V8MC 1.1 ± 0.1d 8.0 (4.0, 10.6)g 5.1 ± 0.4d 
KIF1A(FLAct)-Y89DC 1.4 ± 0.1d 8.5 (4.5, 11.8)h 5.9 ± 0.4d 
KIF1A motorVelocity (μm/s)aRun length (μm)bLanding rate (events⋅min−1⋅nM−1⋅μm−1)c
KIF1A(1–393)C 2.1 ± 0.1 16.7 (10.2, 27.2) 10.7 ± 0.6 
KIF1A(1–393)-V8MC 1.3 ± 0.1e 4.1 (2.1, 7.0)f 1.5 ± 0.1e 
KIF1A(1–393)-Y89DC 1.7 ± 0.1e 2.0 (1.2, 3.5)f 2.8 ± 0.1e 
KIF1A(1–393)-WTE 2.5 ± 0.2 12.2 (6.7, 18.4) ND 
KIF1A(1–393)-V8ME 1.3 ± 0.1 7.3 (4.4, 12.2) ND 
KIF1A(1–393)-Y89DE 1.7 ± 0.2 6.3 (4.0, 10.7) ND 
KIF1A(FL)C 0.3 ± 0.1 2.8 (1.5, 3.7) 2.0 ± 0.2 
KIF1A(FLAct)C 1.9 ± 0.1 9.3 (4.7, 12.7) 2.8 ± 0.6 
KIF1A(FLAct)-V8MC 1.1 ± 0.1d 8.0 (4.0, 10.6)g 5.1 ± 0.4d 
KIF1A(FLAct)-Y89DC 1.4 ± 0.1d 8.5 (4.5, 11.8)h 5.9 ± 0.4d 
a

Data are reported as mean ± SEM.

b

Data are reported as median (quartiles).

c

Includes diffusive + processive events.

d

P < 0.001 (Student’s t test) compared with KIF1A(FLAct)C.

e

P < 0.001 (Student’s t test) compared with KIF1A(1-393)C.

f

P < 0.001 (Kruskal-Wallis test) compared with KIF1A(1-393)C.

g

P = 0.027 (Kruskal-Wallis test) compared with KIF1A(FLAct)C.

h

P = 0.38 (Kruskal-Wallis test) compared with KIF1A(FLAct)C.

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