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Table 2.
KAND-associated mutations that map to the KIF1A motor domain
KIF1A functional regionKAND-associated mutations
MT binding α4: N272S, L278P 
Loop12: P305L 
α5: R307Q, R316W 
α6: R350G 
Nucleotide binding and hydrolysis P loop: T99M and G102S/D 
Loop 9 (switch 1): A202P, S215R, R216P/H/C, S217F 
Loop 11 (switch 2): L249Q, S252R, E253K, R254W/Q, A255V, T258M 
Force generation and motor stepping β1: V8M 
α1-β3: A85D, Y89D 
KIF1A functional regionKAND-associated mutations
MT binding α4: N272S, L278P 
Loop12: P305L 
α5: R307Q, R316W 
α6: R350G 
Nucleotide binding and hydrolysis P loop: T99M and G102S/D 
Loop 9 (switch 1): A202P, S215R, R216P/H/C, S217F 
Loop 11 (switch 2): L249Q, S252R, E253K, R254W/Q, A255V, T258M 
Force generation and motor stepping β1: V8M 
α1-β3: A85D, Y89D 
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