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Table 2.
Effect of aPLs on conductance (G) and open probability (PO) of K+ channels in lipid bilayers
ChannelBilayerNG/pSPO
KcvS PC 10 92 ± 9 −100 mV: 0.40 ± 0.10 
KcvS PS 120 ± 6a −100 mV: 0.89 ± 0.06a 
KcvNTS PC 82 ± 12 −100 mV: 0.93 ± 0.01 
KcvNTS PS 107 ± 5a −100 mV: 0.97 ± 0.01a 
KcvPBCV1 PC 139 ± 11 +100 mV: 0.01 ± 0.004 
KcvPBCV1 PS 191 ± 11a +100 mV: 0.12 ± 0.10a 
KcvNH PC 98 ± 2 +60 mV: 0.47 ± 0.02 
KcvNH PS 138 ± 4a +60 mV: 0.72 ± 0.06a 
KcvMT325 PC 15 34 ± 6 +160 mV: 0.59 ± 0.14 
KcvMT325 PG 10 47 ± 6a +160 mV: 0.70 ± 0.08 
KcvGLD PC 38 ± 4 +160 mV: 0.72 ± 0.07 
KcvGLD PG 91 ± 16a +160 mV: 0.44 ± 0.05 
Kmpv12T PC 10 37 ± 5 −100 mV: 0.21 ± 0.08 
Kmpv12T PS 62 ± 4a −100 mV: 0.10 ± 0.05 
ChannelBilayerNG/pSPO
KcvS PC 10 92 ± 9 −100 mV: 0.40 ± 0.10 
KcvS PS 120 ± 6a −100 mV: 0.89 ± 0.06a 
KcvNTS PC 82 ± 12 −100 mV: 0.93 ± 0.01 
KcvNTS PS 107 ± 5a −100 mV: 0.97 ± 0.01a 
KcvPBCV1 PC 139 ± 11 +100 mV: 0.01 ± 0.004 
KcvPBCV1 PS 191 ± 11a +100 mV: 0.12 ± 0.10a 
KcvNH PC 98 ± 2 +60 mV: 0.47 ± 0.02 
KcvNH PS 138 ± 4a +60 mV: 0.72 ± 0.06a 
KcvMT325 PC 15 34 ± 6 +160 mV: 0.59 ± 0.14 
KcvMT325 PG 10 47 ± 6a +160 mV: 0.70 ± 0.08 
KcvGLD PC 38 ± 4 +160 mV: 0.72 ± 0.07 
KcvGLD PG 91 ± 16a +160 mV: 0.44 ± 0.05 
Kmpv12T PC 10 37 ± 5 −100 mV: 0.21 ± 0.08 
Kmpv12T PS 62 ± 4a −100 mV: 0.10 ± 0.05 

G measured as slope conductance between ± 60 mV. Open probability is presented for each channel for the indicated critical voltage at which a possible difference in PO ± aPLs is most visible. Data are represented as mean ± SD of n independent bilayer recordings.

a

The significance for a difference in G and PO values for PC and PS/PG bilayers is indicated with P values <0.001.

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