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Table 1.
Effect of cholesterol on conductance (G) and open probability (PO) of channels ±30 mol% cholesterol (Chol) in DPhPC bilayers
ChannelChol mol%NG/pSPO −100 mV
KcvS 10 92 ± 9 0.40 ± 0.01 
KcvS 30 100 ± 12 0.53 ± 0.08 
KcvNTS 82 ± 12 0.93 ± 0.01 
KcvNTS 30 97 ± 8 0.91 ± 0.04 
Kmpv12T 10 37 ± 5 0.21 ± 0.08 
Kmpv12T 30 51 ± 9a 0.52 ± 0.16a 
ChannelChol mol%NG/pSPO −100 mV
KcvS 10 92 ± 9 0.40 ± 0.01 
KcvS 30 100 ± 12 0.53 ± 0.08 
KcvNTS 82 ± 12 0.93 ± 0.01 
KcvNTS 30 97 ± 8 0.91 ± 0.04 
Kmpv12T 10 37 ± 5 0.21 ± 0.08 
Kmpv12T 30 51 ± 9a 0.52 ± 0.16a 

G measured as slope conductance between ±60 mV. Open probability is presented for each channel for the critical voltage of −100 mV at which a possible effect of cholesterol on PO is most visible. Data are represented as mean ± SD of n independent bilayer recordings.

a

The significance for a difference in G and PO values ± Chol is indicated with P values <0.01.

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