Skip to Main Content
Table 5.
Parameters used to model MT growth
ParameterDescriptionValue
r0 Width of energy potential well characterizing the length of tubulin–tubulin bond 0.13 nm 
alat Energy parameter for lateral repulsion; corresponds with ∼2 × height of the energy barrier for lateral bond 15 kBT = 9 kcal/mol 
blat Depth of the potential well for lateral bonds 5.3 kBT = 3.2 kcal/mol for MT growth 
4.3 kBT = 2.6 kcal/mol for MT shortening 
along Energy parameter for longitudinal repulsion; corresponds with ∼2 × height of the energy barrier for longitudinal interdimer bond 15 kBT = 9 kcal/mol 
blong Depth of the potential well for longitudinal interdimer bond 16.6 kBT = 10 kcal/mol 
k Stiffness of longitudinal intradimer bond 517 kBT nm−2 = 310 kcal/mol nm−2 
Flexural rigidity of PF bending 58 kBT rad−2 = 35 kcal/mol rad−2 
χD0 Equilibrium angle between GDP-tubulin monomers 0.2 rad 
χT0 Equilibrium angle between GTP-tubulin monomers 0.2 rad 
ctub Soluble tubulin concentration 10 µM 
kon On-rate constant for tubulin addition 8.3 µM−1s−1 per MT 
Temperature 310 K 
η Viscosity 0.2 Pa · s 
dt time step for dynamic algorithm 10−10
Tkin time step for kinetic algorithm 10−3
ParameterDescriptionValue
r0 Width of energy potential well characterizing the length of tubulin–tubulin bond 0.13 nm 
alat Energy parameter for lateral repulsion; corresponds with ∼2 × height of the energy barrier for lateral bond 15 kBT = 9 kcal/mol 
blat Depth of the potential well for lateral bonds 5.3 kBT = 3.2 kcal/mol for MT growth 
4.3 kBT = 2.6 kcal/mol for MT shortening 
along Energy parameter for longitudinal repulsion; corresponds with ∼2 × height of the energy barrier for longitudinal interdimer bond 15 kBT = 9 kcal/mol 
blong Depth of the potential well for longitudinal interdimer bond 16.6 kBT = 10 kcal/mol 
k Stiffness of longitudinal intradimer bond 517 kBT nm−2 = 310 kcal/mol nm−2 
Flexural rigidity of PF bending 58 kBT rad−2 = 35 kcal/mol rad−2 
χD0 Equilibrium angle between GDP-tubulin monomers 0.2 rad 
χT0 Equilibrium angle between GTP-tubulin monomers 0.2 rad 
ctub Soluble tubulin concentration 10 µM 
kon On-rate constant for tubulin addition 8.3 µM−1s−1 per MT 
Temperature 310 K 
η Viscosity 0.2 Pa · s 
dt time step for dynamic algorithm 10−10
Tkin time step for kinetic algorithm 10−3
Close Modal

or Create an Account

Close Modal
Close Modal