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Table I.

Transcription factor activation following treatment of articular chondrocytes with BMP-7


Sample

Smad4

SBE

Pax-1
Control 111.1 ± 1.2 2.4 ± 0.9 53.8 ± 0.7 
+BMP-7 481.2 ± 4.0 29.2 ± 0.4 54.4 ± 1.5 
+BMP-7/+S.H'ase 217.7 ± 11 20.8 ± 1.4 53.6 ± 0.9 
Control 34.6 ± 0.1 
S.H'ase
 
32.0 ± 2.0
 
-
 
-
 

Sample

Smad4

SBE

Pax-1
Control 111.1 ± 1.2 2.4 ± 0.9 53.8 ± 0.7 
+BMP-7 481.2 ± 4.0 29.2 ± 0.4 54.4 ± 1.5 
+BMP-7/+S.H'ase 217.7 ± 11 20.8 ± 1.4 53.6 ± 0.9 
Control 34.6 ± 0.1 
S.H'ase
 
32.0 ± 2.0
 
-
 
-
 

Nuclei were isolated from control chondrocytes or after treatment with BMP-7, Streptomyces hyaluronidase alone (S.H'ase), or co-treatment with BMP-7 and S.H'ase. Transcription factor activation was determined as hybridization signal intensity and presented as the mean ± SEM.

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