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Table I.

Membrane and soluble proteins differ in their requirements for degradation




Membrane proteins

Soluble proteins


Sec61-2p
Ste6-166p
KHN
CPY*
 t1/2 (min) 12 35 27 
Requires CUE1 yes yes yes yes 
 PEP4 no no no no 
 SEC12 no no yes yes 
 SEC18 no no yes yes 
 DER1 no no yes yes 
 HRD1/DER3 yes no yes yes 

 
DOA10
 
ND
 
yes
 
no
 
no
 



Membrane proteins

Soluble proteins


Sec61-2p
Ste6-166p
KHN
CPY*
 t1/2 (min) 12 35 27 
Requires CUE1 yes yes yes yes 
 PEP4 no no no no 
 SEC12 no no yes yes 
 SEC18 no no yes yes 
 DER1 no no yes yes 
 HRD1/DER3 yes no yes yes 

 
DOA10
 
ND
 
yes
 
no
 
no
 

Data complied from Vashist et al., 2001, and this work.

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