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Table I.

Different functions and localizations of TA proteins


Function

Examples

Localization
Enzymatic Cytochrome b(5)
 MOM isoform of cytochrome b(5)
 Heme oxygenase I and II
 UBC6 ER
 MOM
 ER
 ER 
Protein localization   
Translocation Sec61γ, Sec61β
 TOM5, TOM6
 Pex15p ER
 MOM
 Peroxisomes 
Adaptors OMP25 MOM 
Vesicular traffic   
SNARE proteins Target SNAREs (Syntaxins)
 Vesicular SNAREs (e.g., Synaptobrevins) Target membranes for vesicular fusion 
Tethering proteins Giantin Transport vesicles
 Golgi complex 
Regulation of apoptosis (Bcl-2 familyBcl-2
 Bcl-XL
 Bax MOM and ER
 MOM
 Cystol and MOM 
Constituent of viral envelope
 
Us9 protein of α herpes viruses
 
Trans-Golgi network
 

Function

Examples

Localization
Enzymatic Cytochrome b(5)
 MOM isoform of cytochrome b(5)
 Heme oxygenase I and II
 UBC6 ER
 MOM
 ER
 ER 
Protein localization   
Translocation Sec61γ, Sec61β
 TOM5, TOM6
 Pex15p ER
 MOM
 Peroxisomes 
Adaptors OMP25 MOM 
Vesicular traffic   
SNARE proteins Target SNAREs (Syntaxins)
 Vesicular SNAREs (e.g., Synaptobrevins) Target membranes for vesicular fusion 
Tethering proteins Giantin Transport vesicles
 Golgi complex 
Regulation of apoptosis (Bcl-2 familyBcl-2
 Bcl-XL
 Bax MOM and ER
 MOM
 Cystol and MOM 
Constituent of viral envelope
 
Us9 protein of α herpes viruses
 
Trans-Golgi network
 
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