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Table II.

TFF1 treatment and constitutive and induced TFF1 expression induce increased levels of cdk inhibitors


Ckis

TFF1 treatment

Constitutive

Inducible


+
P

+
P

+
P
INK4          
P15 2 ± 0.8 5 ± 0.2 <0.01 15 ± 4.1 37 ± 3.5 <0.01 17 ± 0.4 18 ± 0.5 NS 
P16 44 ± 6.1 61 ± 2.3 <0.05 50 ± 2.5 64 ± 1.8 <0.05 37 ± 2 46 ± 1.5 <0.05 
CIP          
P21 3 ± 1 7 ± 1.1 <0.05 14 ± 3.5 20 ± 4.5 NS 11 ± 0.5 19 ± 1.5 <0.05 
P27
 
13 ± 1.3
 
18 ± 0.8
 
<0.05
 
3 ± 0.2
 
5 ± 1.5
 
<0.05
 
3 ± 1
 
8 ± 1.5
 
<0.05
 

Ckis

TFF1 treatment

Constitutive

Inducible


+
P

+
P

+
P
INK4          
P15 2 ± 0.8 5 ± 0.2 <0.01 15 ± 4.1 37 ± 3.5 <0.01 17 ± 0.4 18 ± 0.5 NS 
P16 44 ± 6.1 61 ± 2.3 <0.05 50 ± 2.5 64 ± 1.8 <0.05 37 ± 2 46 ± 1.5 <0.05 
CIP          
P21 3 ± 1 7 ± 1.1 <0.05 14 ± 3.5 20 ± 4.5 NS 11 ± 0.5 19 ± 1.5 <0.05 
P27
 
13 ± 1.3
 
18 ± 0.8
 
<0.05
 
3 ± 0.2
 
5 ± 1.5
 
<0.05
 
3 ± 1
 
8 ± 1.5
 
<0.05
 
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