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Table I.

Percentage of cells in G1, S, and G2/M phases, and positive for cyclin D1, PCNA, and cyclin B1 proteins after TFF1 treatment and constitutive or induced TFF1 expression


Cell cycle

TFF1 treatment

Constitutive

Inducible

a
+b
P

+
P

+
P
Phase          
G1 58 ± 1.9 81 ± 2.1 <0.01 49 ± 3.4 72 ± 4.0 <0.01 50 ± 2.6 61 ± 2.5 <0.01 
34 ± 2.2 16 ± 2.5 <0.01 38 ± 3.7 23 ± 3.3 <0.01 40 ± 1.3 28 ± 1.5 <0.01 
G2/M 8 ± 1.6 3 ± 0.7 <0.01 13 ± 1.7 5 ± 0.8 <0.01 10 ± 1.1 11 ± 1.2 NS 
Protein          
D1 8 ± 1.2 20 ± 5.7 <0.01 12 ± 3.6 17 ± 0.7 NS 8 ± 1.9 16 ± 1.6 <0.01 
PCNA 62 ± 2.5 2 ± 0.6 <0.01 56 ± 10.2 30 ± 6.2 <0.05 50 ± 2.3 34 ± 5.6 <0.01 
B1
 
5 ± 1.6
 
1 ± 0.8
 
<0.01
 
6 ± 2.5
 
5 ± 2.1
 
NS
 
9 ± 1.2
 
1 ± 0.6
 
<0.01
 

Cell cycle

TFF1 treatment

Constitutive

Inducible

a
+b
P

+
P

+
P
Phase          
G1 58 ± 1.9 81 ± 2.1 <0.01 49 ± 3.4 72 ± 4.0 <0.01 50 ± 2.6 61 ± 2.5 <0.01 
34 ± 2.2 16 ± 2.5 <0.01 38 ± 3.7 23 ± 3.3 <0.01 40 ± 1.3 28 ± 1.5 <0.01 
G2/M 8 ± 1.6 3 ± 0.7 <0.01 13 ± 1.7 5 ± 0.8 <0.01 10 ± 1.1 11 ± 1.2 NS 
Protein          
D1 8 ± 1.2 20 ± 5.7 <0.01 12 ± 3.6 17 ± 0.7 NS 8 ± 1.9 16 ± 1.6 <0.01 
PCNA 62 ± 2.5 2 ± 0.6 <0.01 56 ± 10.2 30 ± 6.2 <0.05 50 ± 2.3 34 ± 5.6 <0.01 
B1
 
5 ± 1.6
 
1 ± 0.8
 
<0.01
 
6 ± 2.5
 
5 ± 2.1
 
NS
 
9 ± 1.2
 
1 ± 0.6
 
<0.01
 
a

−, Absence of TFF1 treatment or synthesis.

b

+, Presence of TFF1 treatment or synthesis.

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