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Table 4

100–10,000-fold Excess of Growth Factors Is Insufficient to Rescue the Dominant Negative FGFR Mutant

Growth factorsApproximate concentration in growth factor–reduced MatrigelGrowth factor added to mutant (ng/ml)Difference of concentration
FGF2 0.004 pg/ml 25 6.25 × 103 
EGF 20 pg/ml 10 5 × 102 
Insulin 0.2 ng/ml 20 1 × 102 
PDGF-BB 0.00 ng/ml 20 2 × 104 
Growth factorsApproximate concentration in growth factor–reduced MatrigelGrowth factor added to mutant (ng/ml)Difference of concentration
FGF2 0.004 pg/ml 25 6.25 × 103 
EGF 20 pg/ml 10 5 × 102 
Insulin 0.2 ng/ml 20 1 × 102 
PDGF-BB 0.00 ng/ml 20 2 × 104 
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