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Table 1

Tight Junction Proteins

TJ proteinsStructural featuresFunctionKnown partners
Claudins 4 TM, COOH-YV TJ barrier ZO-11 
Occludin 4 TM TJ barrier ZO-1, ZO-2, Vap33, actin1–3 
JAM 1 TM, Ig-like Monocyte transmigration4  
ZO-1 3 PDZ, 1SH3, GUK Scaffold protein, signaling molecule Occludin, claudins, ZO-2, -3, cingulin, actin, ZONAB1,2,5,6 
ZO-2 3 PDZ, 1SH3, GUK Scaffold protein ZO-1, actin2 
ZO-3 3 PDZ, 1SH3, GUK Scaffold protein ZO-1, occludin2 
AF-6 PDZ Scaffold protein Ras, ZO-17 
Dlg (Drosophila3 PDZ, 1SH3, GUK Scaffold protein, signaling molecule8  
Scribble (Drosophila4 PDZ Fence/membrane traffic9  
Cingulin coiled coil  ZO-1, -2, -3, occludin, myosin5 
Symplekin  Signaling molecule10  
ASIP/Par3 3 PDZ Signaling molecule PKC ζ11,12,13 
Rab3b GDP/GTP binding Membrane traffic14  
Rab13 GDP/GTP binding Membrane traffic δ-PDE15,16 
Rab8 GDP/GTP binding Membrane traffic G/C kinase17,18 
Sec6, Sec8  Vesicle docking Exocyst subunits19 
TJ proteinsStructural featuresFunctionKnown partners
Claudins 4 TM, COOH-YV TJ barrier ZO-11 
Occludin 4 TM TJ barrier ZO-1, ZO-2, Vap33, actin1–3 
JAM 1 TM, Ig-like Monocyte transmigration4  
ZO-1 3 PDZ, 1SH3, GUK Scaffold protein, signaling molecule Occludin, claudins, ZO-2, -3, cingulin, actin, ZONAB1,2,5,6 
ZO-2 3 PDZ, 1SH3, GUK Scaffold protein ZO-1, actin2 
ZO-3 3 PDZ, 1SH3, GUK Scaffold protein ZO-1, occludin2 
AF-6 PDZ Scaffold protein Ras, ZO-17 
Dlg (Drosophila3 PDZ, 1SH3, GUK Scaffold protein, signaling molecule8  
Scribble (Drosophila4 PDZ Fence/membrane traffic9  
Cingulin coiled coil  ZO-1, -2, -3, occludin, myosin5 
Symplekin  Signaling molecule10  
ASIP/Par3 3 PDZ Signaling molecule PKC ζ11,12,13 
Rab3b GDP/GTP binding Membrane traffic14  
Rab13 GDP/GTP binding Membrane traffic δ-PDE15,16 
Rab8 GDP/GTP binding Membrane traffic G/C kinase17,18 
Sec6, Sec8  Vesicle docking Exocyst subunits19 

Exponent numbers indicate references: 1, Itoh et al., 1999; 2, Wittchen et al., 1999; 3, Lapierre et al., 1999; 4, Martin-Padura et al., 1998; 5, Cordenonsi et al., 1999; 6, Balda and Matter, 2000; 7, Yamamoto et al., 1997; 8, Woods and Bryant, 1991; 9, Bilder and Perrimon, 2000a; 10, Keon et al., 1996; 11, Joberty et al., 2000; 12, Lin et al., 2000; 13, Izumi et al., 1998; 14, Weber et al., 1994; 15, Zahraoui et al., 1994; 16, Marzesco et al., 1998; 17, Huber et al., 1993; 18, Ren et al., 1996; and 19, Grindstaff et al., 1998.

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