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Table 2

Genotype Analysis of Compound Knockout Crosses

F1 genotypesKrt2-8 (+/+): Krt1-19 (−/−)Krt2-8 (+/−): Krt1-19 (−/−)Krt2-8 (−/−): Krt1-19 (−/−)Necrotic or resorption
7.5–9.5 dpc 24 34 18 
10.5 dpc 14 27 4* 
11.5–13.0 dpc 13 
Postnatal 79 140 — 
F1 genotypesKrt2-8 (+/+): Krt1-19 (−/−)Krt2-8 (+/−): Krt1-19 (−/−)Krt2-8 (−/−): Krt1-19 (−/−)Necrotic or resorption
7.5–9.5 dpc 24 34 18 
10.5 dpc 14 27 4* 
11.5–13.0 dpc 13 
Postnatal 79 140 — 

Parents: K8 (Krt2-8, +/−):K19 (Krt1-19, −/−) × K8 (Krt2-8, +/−):K19 (Krt1-19, −/−). Parents were after the sixth backcross generation into the FVB/N background.

*Embryos with abnormal morphology.

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