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Table 2

Summary of per Mutant Characterization

AlleleGeneTemperature conditional phenotypeInteraction with ΔireProtein processing defectSuppressing by Hac1ip
per1-1  ts SN Gas1p No 
per1-2   SN  Yes 
per2-1 MCD4 ts SL Gas1p Yes 
per3-1   SL Glycosylation Yes 
per4-1 LHS1  SL  Yes 
per4-2 LHS1 cs SL  Yes 
per5-1 RFT1  SL Glycosylation Yes 
per6-1   SL Glycosylation Yes 
per6-2  ts SL Glycosylation Yes 
per7-1   SL CPY*HA degradation Yes 
per8-1 SON1 cs SL CPY*HA degradation Yes 
per9-1   SL Gas1p/CPY*HA degradation Yes 
per10-1   SL  Yes 
per10-2   SL  Yes 
per11-1   SN  Yes 
per12-1  ts SL Glycosylation Yes 
per13-1 GPI10 ts SN Gas1p/CPY*HA degradation Yes 
per14-1   SL Glycosylation Yes 
per15-1  ts/cs SL Gas1p No 
per16-1 UBC7  SN CPY*HA degradation Yes 
AlleleGeneTemperature conditional phenotypeInteraction with ΔireProtein processing defectSuppressing by Hac1ip
per1-1  ts SN Gas1p No 
per1-2   SN  Yes 
per2-1 MCD4 ts SL Gas1p Yes 
per3-1   SL Glycosylation Yes 
per4-1 LHS1  SL  Yes 
per4-2 LHS1 cs SL  Yes 
per5-1 RFT1  SL Glycosylation Yes 
per6-1   SL Glycosylation Yes 
per6-2  ts SL Glycosylation Yes 
per7-1   SL CPY*HA degradation Yes 
per8-1 SON1 cs SL CPY*HA degradation Yes 
per9-1   SL Gas1p/CPY*HA degradation Yes 
per10-1   SL  Yes 
per10-2   SL  Yes 
per11-1   SN  Yes 
per12-1  ts SL Glycosylation Yes 
per13-1 GPI10 ts SN Gas1p/CPY*HA degradation Yes 
per14-1   SL Glycosylation Yes 
per15-1  ts/cs SL Gas1p No 
per16-1 UBC7  SN CPY*HA degradation Yes 

per mutant allele designations listed with corresponding gene names, if known. ts, Temperature-sensitive: impaired or no growth at 37 °C; cs, cold-sensitive: impaired or no growth at 16°C; SL, synthetic lethal: mutation is lethal in combination with Δire1, as determined by tetrad analysis; SN, synthetically negative: mutation causes severely impaired growth in combination with Δire1, as determined by tetrad analysis.

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