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Table I

Comparison of Parasitaemias Produced on Infection of Mice with Various Trypanosome Lines; Mann-Whitney Tests Were Used to Compare Experimental Groups with the Control (Ia) or PLC with PLC+ (Ib), and p Values Are Given in Brackets

Trypanosome lineMedian no. of troughs*Parasitaemia at first peakNo. of days pd >1 × 108 (%)§No. of days pd <1 × 107 (%)§Mean survival time
Ia           
           
Control   1.4 × 108  3.5 (17.5)   6.5 (32.5)  28.0 
PLC   4.1 × 107 (P = 0.01)   12.8 (64.2)  81.3 (P = 0.01) 
PLC22p   7.4 × 107 (P = 0.01)  1.2 (6.0)  11.2 (56)  72.8 (P = 0.05) 
PLC22p 1 × 107  1–2  7.2 × 107 (P = 0.11)  1.2 (6.0)  10.2 (50.8)  90.5 (P = 0.01) 
           
Ib           
           
PLC   2.4 × 107  0.2 (0.8)  14.7 (73.3)  74.3 
PLC+  1–2  9.4 × 107 (P = 0.01)  2.2 (10.8)   9.7 (48.3)  56.7 (P = 0.26) 
Trypanosome lineMedian no. of troughs*Parasitaemia at first peakNo. of days pd >1 × 108 (%)§No. of days pd <1 × 107 (%)§Mean survival time
Ia           
           
Control   1.4 × 108  3.5 (17.5)   6.5 (32.5)  28.0 
PLC   4.1 × 107 (P = 0.01)   12.8 (64.2)  81.3 (P = 0.01) 
PLC22p   7.4 × 107 (P = 0.01)  1.2 (6.0)  11.2 (56)  72.8 (P = 0.05) 
PLC22p 1 × 107  1–2  7.2 × 107 (P = 0.11)  1.2 (6.0)  10.2 (50.8)  90.5 (P = 0.01) 
           
Ib           
           
PLC   2.4 × 107  0.2 (0.8)  14.7 (73.3)  74.3 
PLC+  1–2  9.4 × 107 (P = 0.01)  2.2 (10.8)   9.7 (48.3)  56.7 (P = 0.26) 
*

 A trough is defined as a drop in parasitaemia greater than one order of magnitude between adjacent time points (calculated for the first 40 d).  

 Geometric means of parasite density at the peak of the first wave of parasitaemia (n = 6, except for PLC 22p, where n = 5).  

§

 The mean number of days on which parasite density (pd) was ⩾1 × 108 cells per ml of blood, or ⩽1 × 107 cells per ml of blood. These were determined for the first 20 d after infection and are expressed as percentages in parentheses.  

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