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Table I

Primary Structure of the LAMP Chimeras

ChimeraAmino acids from LAMP-1Amino acids from LAMP-2
L/2a/2a  F1-V345  NKFSIAEDCSPEVDY.FIVP  IAVGAALGGLVVLVIMAYFLG  HKKHHNTGYEQF 
L/2b/2b  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQSV 
L/2c/2c  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSYAGYQTL 
L/2c/2b  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSRTGYQSV 
L/2b/2c  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSYAGYQTL 
L/2b/2b R391Y  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSYTGYQSV 
L/2b/2b S396T  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQTV 
L/2b/2b V397L  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQSL 
L/2b/2b S396T, V397L  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQTL 
L/2c/2c L396V  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSYAGYQTL 
         
Structure  Lumenal/extracellular domain  Transmembrane domain  Cytoplasmic tail 
ChimeraAmino acids from LAMP-1Amino acids from LAMP-2
L/2a/2a  F1-V345  NKFSIAEDCSPEVDY.FIVP  IAVGAALGGLVVLVIMAYFLG  HKKHHNTGYEQF 
L/2b/2b  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQSV 
L/2c/2c  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSYAGYQTL 
L/2c/2b  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSRTGYQSV 
L/2b/2c  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSYAGYQTL 
L/2b/2b R391Y  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSYTGYQSV 
L/2b/2b S396T  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQTV 
L/2b/2b V397L  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQSL 
L/2b/2b S396T, V397L  F1-V345  NKFSIAEECFADSDLNFLIP  VAVGMALGFLIILVFISYIIG  .RRKSRTGYQTL 
L/2c/2c L396V  F1-V345  NKFSIAQECSLDDD.TILIP  IVVGAALAGLIVIIVIAYIIG  .RRKSYAGYQTL 
         
Structure  Lumenal/extracellular domain  Transmembrane domain  Cytoplasmic tail 
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