Vascular Tumors Induced by PymT Virus and Establishment of End. Cell Lines
| Tumors . | . | End. cell lines . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype . | . | Latency . | . | Penetrance . | . | Name . | Abbr. . | . | Origin . | |
| d | ||||||||||
| wt+/+ | 8–10 | 29/30 | bEnd.1 | b1 | brain | |||||
| eEnd.2 | e2 | yolk sac | ||||||||
| mEnd.3 | m3 | mesentery | ||||||||
| sEnd.1 | s1 | skin | ||||||||
| sEnd.2 | s2 | skin thorax | ||||||||
| uPA−/− | 10–13 | 9/10 | mEnd.u23 | u23 | mesentery | |||||
| sEnd.u24 | u24 | skin thorax | ||||||||
| tPA−/− | 11–13 | 8/8 | mEnd.t37 | t37 | mesentery | |||||
| pEnd.t38 | t38 | pancreas | ||||||||
| uPA−/− tPA−/− | 12–14 | 11/11 | sEnd.ut1 | ut1 | skin sternum | |||||
| liEnd.ut2 | ut2 | liver | ||||||||
| PAI-1−/− | 6–8 | 3/3 | luEnd.p1 | p1 | lung | |||||
| liEnd.p3 | p3 | liver | ||||||||
| Plg−/− | 8–12 | 9/9 | ND | |||||||
| Tumors . | . | End. cell lines . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype . | . | Latency . | . | Penetrance . | . | Name . | Abbr. . | . | Origin . | |
| d | ||||||||||
| wt+/+ | 8–10 | 29/30 | bEnd.1 | b1 | brain | |||||
| eEnd.2 | e2 | yolk sac | ||||||||
| mEnd.3 | m3 | mesentery | ||||||||
| sEnd.1 | s1 | skin | ||||||||
| sEnd.2 | s2 | skin thorax | ||||||||
| uPA−/− | 10–13 | 9/10 | mEnd.u23 | u23 | mesentery | |||||
| sEnd.u24 | u24 | skin thorax | ||||||||
| tPA−/− | 11–13 | 8/8 | mEnd.t37 | t37 | mesentery | |||||
| pEnd.t38 | t38 | pancreas | ||||||||
| uPA−/− tPA−/− | 12–14 | 11/11 | sEnd.ut1 | ut1 | skin sternum | |||||
| liEnd.ut2 | ut2 | liver | ||||||||
| PAI-1−/− | 6–8 | 3/3 | luEnd.p1 | p1 | lung | |||||
| liEnd.p3 | p3 | liver | ||||||||
| Plg−/− | 8–12 | 9/9 | ND | |||||||
Supernatants from PymT-producing fibroblasts were injected into newborn wild-type and mutant mice, which were propagated by brother–sister matings. All mutant End. cell lines were established from C57Bl/6 × 129 mice. The derivation of the wild-type End. cell lines was previously described; for details regarding establishment, see Materials and Methods.