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Table 2.
Analysis of the kinetics of the calcium transients in EOM fibers and myotubes from WT and ryr3−/−mice
Type of Ca2+ responseGenotype and cell typePeak Ca2+ (ΔF) TTHP (ms) TTP (ms) HRT (ms)
Electrically evoked transient parameters WT EOM fibers 0.458 ± 0.036 (n = 14) 0.621 ± 0.019 (n = 12) 1.042 ± 0.032 (n = 12) 1.147 ± 0.125 (n = 12) 
ryr3−/− EOM fibers 0.424 ± 0.027 (n = 21) 0.718 ± 0.034* (n = 19) 1.310 ± 0.159 (n = 19) 5.531 ± 0.877*** (n = 19) 
Spontaneous Ca2+ transient parameters WT myotubes 0.506 ± 0.003 (n = 9,319) 20.598 ± 0.192 (n = 9,319) 29.885 ± 0.347 (n = 9319) 77.813 ± 0.8138 (n = 8,941) 
ryr3−/− myotubes 0.6111 ± 0.010***** (n = 1,368) 27.527 ± 0.570***** (n = 1,368) 46.878 ± 1.173***** (n = 1,368) 87.586 ± 1.931***** (n = 1,339) 
Type of Ca2+ responseGenotype and cell typePeak Ca2+ (ΔF) TTHP (ms) TTP (ms) HRT (ms)
Electrically evoked transient parameters WT EOM fibers 0.458 ± 0.036 (n = 14) 0.621 ± 0.019 (n = 12) 1.042 ± 0.032 (n = 12) 1.147 ± 0.125 (n = 12) 
ryr3−/− EOM fibers 0.424 ± 0.027 (n = 21) 0.718 ± 0.034* (n = 19) 1.310 ± 0.159 (n = 19) 5.531 ± 0.877*** (n = 19) 
Spontaneous Ca2+ transient parameters WT myotubes 0.506 ± 0.003 (n = 9,319) 20.598 ± 0.192 (n = 9,319) 29.885 ± 0.347 (n = 9319) 77.813 ± 0.8138 (n = 8,941) 
ryr3−/− myotubes 0.6111 ± 0.010***** (n = 1,368) 27.527 ± 0.570***** (n = 1,368) 46.878 ± 1.173***** (n = 1,368) 87.586 ± 1.931***** (n = 1,339) 

Experiments were performed at room temperature. Values represent mean ± SEM. *, P < 0.05; ***, P < 0.001, Student’s t test; *****, P < 0.00001, Welch's t test.

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