Table 2.
Properties and occupancy of the two activity states in the Heeley et al. (2019) two-state model
StatesIA
ATPaseLowHigh
Occupancy +Tn −Ca 0.95 (0.95) 0.05 (0.05)
+Tn +Ca 0.25 (0.8) 0.75 (0.2)
+Myosin (ratio of myosin: actin, 1:7) 0.33 (0) 0.67 (1.0)
StatesIA
ATPaseLowHigh
Occupancy +Tn −Ca 0.95 (0.95) 0.05 (0.05)
+Tn +Ca 0.25 (0.8) 0.75 (0.2)
+Myosin (ratio of myosin: actin, 1:7) 0.33 (0) 0.67 (1.0)

The occupancy is based on the Keq values given in Scheme 2 of Heeley et al. (2019) where Keq is the equilibrium constant between the A and I states. The values in brackets are the occupancies predicted by the earlier two-state model of Hill et al. (1980).

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