Table 1.
Amiloride-sensitive currents in oocytes expressing ENaC mutants
ConstructINa (μA)n
WT 12.1 ± 0.6 7 
αE595Q/β/γ 1.2 ± 0.3 5 
α/βE537Q/γ 6.1 ± 1.2 4 
α/β/γE549Q 10.0±1.8 5 
α/βE537Q/γE549Q 0.31 ± 0.06 4 
αE595Q/β/γE549Q 0.22 ± 0.05 7 
αE595Q/βE537Q/γ 0.13 ± 0.02 3 
αE598Q/β/γ 2.5 ± 0.2 3 
α/βE540Q/γ 0.43 ± 0.08 4 
α/β/γE552Q 0.85 ±0.31 7 
α/βT/γ 11.3 ± 2.7 3 
α5E95Q/βT/γE549Q 0.22 ± 0.05 4 
αE598Q/βT/γE552Q 0.18 ± 0.06 5 
WT 5.8 ± 0.5 3 
αC506S/β/γ 13.6 ± 2.1 4 
αC506S/βT/γ 18.3 ± 1.4 5 
αC506S,E595Q/βT E573Q/γ 0.80 ± 0.16 3 
αC506S/βTE573Q/γE549Q 0.57 ± 0.09 4 
ConstructINa (μA)n
WT 12.1 ± 0.6 7 
αE595Q/β/γ 1.2 ± 0.3 5 
α/βE537Q/γ 6.1 ± 1.2 4 
α/β/γE549Q 10.0±1.8 5 
α/βE537Q/γE549Q 0.31 ± 0.06 4 
αE595Q/β/γE549Q 0.22 ± 0.05 7 
αE595Q/βE537Q/γ 0.13 ± 0.02 3 
αE598Q/β/γ 2.5 ± 0.2 3 
α/βE540Q/γ 0.43 ± 0.08 4 
α/β/γE552Q 0.85 ±0.31 7 
α/βT/γ 11.3 ± 2.7 3 
α5E95Q/βT/γE549Q 0.22 ± 0.05 4 
αE598Q/βT/γE552Q 0.18 ± 0.06 5 
WT 5.8 ± 0.5 3 
αC506S/β/γ 13.6 ± 2.1 4 
αC506S/βT/γ 18.3 ± 1.4 5 
αC506S,E595Q/βT E573Q/γ 0.80 ± 0.16 3 
αC506S/βTE573Q/γE549Q 0.57 ± 0.09 4 

Currents measured at Vm = −150 mV. Data given as means ± SEM.

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