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Table 2.
Macroscopic current amplitudes for GluN1/GluN2A containing tryptophan substitutions in the VVLGAVE face in the GluN1 and GluN2A M4 segments
ConstructIpeaknComments
  pA   
 N1/N2A −750 ± 50 18  
N1(M813W)/N2A(M817W) ND  
N1(V816W)/N2A(V820W) NT N1/N2A(V820W) showed no current 
N1(V820W)/N2A(L824W) −340 ± 35  
N1(G823W)/N2A(A827W) −535 ± 60  
N1(G827W)/N2A(S831W) NT N1/N2A(S831W) showed no current 
N1(L830W)/N2A(T834W) −570 ± 140  
N1(E834W)/N2A(E838W) ND  
ConstructIpeaknComments
  pA   
 N1/N2A −750 ± 50 18  
N1(M813W)/N2A(M817W) ND  
N1(V816W)/N2A(V820W) NT N1/N2A(V820W) showed no current 
N1(V820W)/N2A(L824W) −340 ± 35  
N1(G823W)/N2A(A827W) −535 ± 60  
N1(G827W)/N2A(S831W) NT N1/N2A(S831W) showed no current 
N1(L830W)/N2A(T834W) −570 ± 140  
N1(E834W)/N2A(E838W) ND  

Values shown are mean ± SEM. Currents recorded as in Fig. 1. n indicates the number of whole-cell recordings. None of the constructs that showed current were significantly different from wild type (P < 0.05, two-tailed Student’s t test, unpaired). NT, not tested. ND, no glutamate-activated currents detected.

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