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Table 1.

Comparison of tsA201 experiments and simulations

Property Experiment Model 
Pipette resistance (MΩ) 3–5 4.4 
Plasma membrane area (pF//µm2) 20//2,000 8.0//804 
Diffusion coefficient melatonin (cm2/s) 6 × 10−6a 6 × 10−6 
Cell-bath equilibration time constant for melatonin (s) 3.5 3.54 
Membrane permeability melatonin (µm/s) - 1.7 
Exponential melatonin space constant outside cell (µm) 30 22 
Extracellular concentration with 10 mM melatonin in the whole-cell pipette (µM) 2.8 11.6 
Extracellular concentration with 10 mM melatonin in the on-cell pipette (µM) 0.56 2.3 
Property Experiment Model 
Pipette resistance (MΩ) 3–5 4.4 
Plasma membrane area (pF//µm2) 20//2,000 8.0//804 
Diffusion coefficient melatonin (cm2/s) 6 × 10−6a 6 × 10−6 
Cell-bath equilibration time constant for melatonin (s) 3.5 3.54 
Membrane permeability melatonin (µm/s) - 1.7 
Exponential melatonin space constant outside cell (µm) 30 22 
Extracellular concentration with 10 mM melatonin in the whole-cell pipette (µM) 2.8 11.6 
Extracellular concentration with 10 mM melatonin in the on-cell pipette (µM) 0.56 2.3 
a

Rice et al. (1985).

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