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Table 2.
Time constants of current activation
ConstructsKineticsTime constant (ms)PN
MeanSDSEM
CaV1.1a slow  43.3 25.8 4.7  na,††† 30 
 fast  7.4 3.6 0.6  na,ns  
CaV1.1e slow  22.6 13.9 3.1  ***,na 20 
 fast  4.4 2.3 0.5  ns,na  
CaV1.1a-L1212/1215slow  16.5 7.4 2.6  ***,ns 
 fast  4.5 2.6 0.9  ns,ns  
CaV1.1e-LI   4.1 3.0 0.6  na 25 
CaV1.1e-L4I   2.7 1.3 0.5  ns 
CaV1.1e-3LI   4.1 1.6 0.6  ns 
CaV1.1a-CSI   3.3 0.9 0.3  ns 12 
CaV1.1e-CSI mono  4.7 2.1 0.8  ns 
CaV1.1e-LI-3LIV   4.0 1.9 0.5  ns 14 
CaV1.1e-LI-L4IV   10.4 2.7 0.8  °°° 12 
CaV1.1e-LI-LIV   4.1 1.6 0.4  ns 18 
CaV1.1e-LI-3L4IV   2.6 0.7 0.2  ns 
ConstructsKineticsTime constant (ms)PN
MeanSDSEM
CaV1.1a slow  43.3 25.8 4.7  na,††† 30 
 fast  7.4 3.6 0.6  na,ns  
CaV1.1e slow  22.6 13.9 3.1  ***,na 20 
 fast  4.4 2.3 0.5  ns,na  
CaV1.1a-L1212/1215slow  16.5 7.4 2.6  ***,ns 
 fast  4.5 2.6 0.9  ns,ns  
CaV1.1e-LI   4.1 3.0 0.6  na 25 
CaV1.1e-L4I   2.7 1.3 0.5  ns 
CaV1.1e-3LI   4.1 1.6 0.6  ns 
CaV1.1a-CSI   3.3 0.9 0.3  ns 12 
CaV1.1e-CSI mono  4.7 2.1 0.8  ns 
CaV1.1e-LI-3LIV   4.0 1.9 0.5  ns 14 
CaV1.1e-LI-L4IV   10.4 2.7 0.8  °°° 12 
CaV1.1e-LI-LIV   4.1 1.6 0.4  ns 18 
CaV1.1e-LI-3L4IV   2.6 0.7 0.2  ns 

The activation of CaV1.1a, CaV1.1e, and CaV1.1a-L1212/1215N was fitted by a double-exponential function, whereas all other currents were best fitted with a mono-exponential function. Numerical values represent mean, SD, and SEM. Statistical differences between mutants, chimeras, and CaV1.1a or CaV1.1e were measured with one-way ANOVA, followed by a Bonferroni multiple comparison test. Significant differences against CaV1.1a are indicated as ***, P < 0.0001. Differences against CaV1.1e are indicated as †††, P < 0.0001. For mono-exponential time constants, differences against CaV1.1e-LI are indicated as °°°, P < 0.0001. ns, not significant (P < 0.05); na, not applicable.

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