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Table 1.
Voltage of half-maximal activation (V1/2) and current density at maximal activation (Ipeak)
ConstructsV1/2 (mV)Ipeak (pA/pF)N
MeanSDSEMPMeanSDSEMP
CaV1.1a  34.8 4.9 0.9 na,†††  1.8 0.7 0.1 na,†††  31 
CaV1.1e  6.7 5.7 1.0 ***,na  10.5 4.3 0.7 ***,na  30 
CaV1.1a-L1212/1215 23.0 5.1 1.5 ***,†††  4.8 2.4 0.7 ns,ns  12 
CaV1.1e-LI  11.7 4.5 0.9 ***,  12.5 6.6 1.3 ***,ns  25 
CaV1.1e-L4I  36.4 8.3 3.1 ns,†††  0.6 0.2 0.1 ns,†††  
CaV1.1e-3LI  12.4 3.8 1.4 ***,ns  5.8 2.3 0.8 ns,ns  
CaV1.1a-CSI  31.3 4.0 1.1 ns,†††  2.3 1.8 0.5 ns,†††  12 
CaV1.1e-CSI  −1.6 6.4 2.1 ***,††  12.0 8.3 2.7 ***,ns  
CaV1.1e-LI-3LIV  36.1 5.7 1.5 ns,†††  2.1 1.2 0.3 ns,†††  14 
CaV1.1e-LI-L4IV  5.2 3.3 0.9 ***,ns  9.6 4.3 1.2 ***,ns  12 
CaV1.1e-LI-LIV  21.2 7.3 1.7 ***,†††  7.0 3.1 0.7 ***,ns  18 
CaV1.1e-LI-3L4IV  10.6 5.3 2.0 ***,ns  8.7 4.5 1.7 **,ns  
ConstructsV1/2 (mV)Ipeak (pA/pF)N
MeanSDSEMPMeanSDSEMP
CaV1.1a  34.8 4.9 0.9 na,†††  1.8 0.7 0.1 na,†††  31 
CaV1.1e  6.7 5.7 1.0 ***,na  10.5 4.3 0.7 ***,na  30 
CaV1.1a-L1212/1215 23.0 5.1 1.5 ***,†††  4.8 2.4 0.7 ns,ns  12 
CaV1.1e-LI  11.7 4.5 0.9 ***,  12.5 6.6 1.3 ***,ns  25 
CaV1.1e-L4I  36.4 8.3 3.1 ns,†††  0.6 0.2 0.1 ns,†††  
CaV1.1e-3LI  12.4 3.8 1.4 ***,ns  5.8 2.3 0.8 ns,ns  
CaV1.1a-CSI  31.3 4.0 1.1 ns,†††  2.3 1.8 0.5 ns,†††  12 
CaV1.1e-CSI  −1.6 6.4 2.1 ***,††  12.0 8.3 2.7 ***,ns  
CaV1.1e-LI-3LIV  36.1 5.7 1.5 ns,†††  2.1 1.2 0.3 ns,†††  14 
CaV1.1e-LI-L4IV  5.2 3.3 0.9 ***,ns  9.6 4.3 1.2 ***,ns  12 
CaV1.1e-LI-LIV  21.2 7.3 1.7 ***,†††  7.0 3.1 0.7 ***,ns  18 
CaV1.1e-LI-3L4IV  10.6 5.3 2.0 ***,ns  8.7 4.5 1.7 **,ns  

Numerical values represent mean, SD, SEM, and number of samples (N). Statistical differences between mutants, chimeras, and CaV1.1a or CaV1.1e were determined with one-way ANOVA, followed by a Bonferroni multiple comparison test. Significant differences against CaV1.1a are indicated as **, P < 0.001; ***, P < 0.0001. Differences against CaV1.1e are indicated as , P < 0.05; ††, P < 0.001; †††, P < 0.0001. ns, not significant (P < 0.05); na, not applicable.

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