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Table 2.

Canonical CaM-binding motifs in helix B of KCNQ channels

Motif KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 
 Residues Sequence Residues Sequence Residues Sequence Residues Sequence Residues Sequence 
1–10 514–523 IKVIRRMQYF 536–545 LKVSIRAVCV 515–524 LKAAIRAVRI 530–539 VKTVIRSIRI 518–527 LKTVIRAIRI 
   540–549 IRAVCVMRFL 525–534 LQFRLYKKKF 533–542 VIRSIRILKF 521–530 VIRAIRIMKF 
       534–543 IRSIRILKFL   
       540–549 LKFLVAKRKF   
1–5–10   536–545 LKVSIRAVCV 515–524 LKAAIRAVRI 530–539 VKTVIRSIRI 518–527 LKTVIRAIRI 
     525–534 LQFRLYKKKF 533–542 VIRSIRILKF 521–530 VIRAIRIMKF 
       540–549 LKFLVAKRKF   
1–12 506–517 LREHHRATIKVI 532–543 LTPGLKVSIRAV   526–537 IMPAVKTVIRSI 514–525 LTPPLKTVIRAI 
   538–549 VSIRAVCVMRFL   533–544 VIRSIRILKFLV 521–532 VIRAIRIMKFHV 
1–14 516–529 VIRRMQYFVAKKKF 532–545 LTPGLKVSIRAVCV 512–525 IPTLKAAIRAVRIL 526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
   536–549 LKVSIRAVCVMRFL   530–543 VKTVIRSIRILKFL   
1–8–14 516–529 VIRRMQYFVAKKKF 536–549 LKVSIRAVCVMRFL 512–525 IPTLKAAIRAVRIL 526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
       530–543 VKTVIRSIRILKFL   
1–5–8–14   536–549 LKVSIRAVCVMRFL   526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
       530–543 VKTVIRSIRILKFL   
1–16 514–529 IKVIRRMQYFVAKKK 540–555 IRAVCVMRFLVSKRK 512–527 IPTLKAAIRAVRILQF 534–549 IRSIRILKFLVAKRKF 522–537 IRAIRIMKFHVAKRKF 
     519–534 IRAVRILQFRLYKKKF     
Motif KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 
 Residues Sequence Residues Sequence Residues Sequence Residues Sequence Residues Sequence 
1–10 514–523 IKVIRRMQYF 536–545 LKVSIRAVCV 515–524 LKAAIRAVRI 530–539 VKTVIRSIRI 518–527 LKTVIRAIRI 
   540–549 IRAVCVMRFL 525–534 LQFRLYKKKF 533–542 VIRSIRILKF 521–530 VIRAIRIMKF 
       534–543 IRSIRILKFL   
       540–549 LKFLVAKRKF   
1–5–10   536–545 LKVSIRAVCV 515–524 LKAAIRAVRI 530–539 VKTVIRSIRI 518–527 LKTVIRAIRI 
     525–534 LQFRLYKKKF 533–542 VIRSIRILKF 521–530 VIRAIRIMKF 
       540–549 LKFLVAKRKF   
1–12 506–517 LREHHRATIKVI 532–543 LTPGLKVSIRAV   526–537 IMPAVKTVIRSI 514–525 LTPPLKTVIRAI 
   538–549 VSIRAVCVMRFL   533–544 VIRSIRILKFLV 521–532 VIRAIRIMKFHV 
1–14 516–529 VIRRMQYFVAKKKF 532–545 LTPGLKVSIRAVCV 512–525 IPTLKAAIRAVRIL 526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
   536–549 LKVSIRAVCVMRFL   530–543 VKTVIRSIRILKFL   
1–8–14 516–529 VIRRMQYFVAKKKF 536–549 LKVSIRAVCVMRFL 512–525 IPTLKAAIRAVRIL 526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
       530–543 VKTVIRSIRILKFL   
1–5–8–14   536–549 LKVSIRAVCVMRFL   526–539 IMPAVKTVIRSIRI 514–527 LTPPLKTVIRAIRI 
       530–543 VKTVIRSIRILKFL   
1–16 514–529 IKVIRRMQYFVAKKK 540–555 IRAVCVMRFLVSKRK 512–527 IPTLKAAIRAVRILQF 534–549 IRSIRILKFLVAKRKF 522–537 IRAIRIMKFHVAKRKF 
     519–534 IRAVRILQFRLYKKKF     

CaM motifs are described in Table 1.

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