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Table 1.

Canonical CaM-binding motifs

Motif Sequence 
Ca2+ dependent  
1–10 [FILVW]xxxxxxxx[FILVW] 
1–5–10 [FILVW]xxx[FAILVW]xxxx[FILVW] 
Basic 1–5–10 [RK][RK][RK][FAILVW]xxx[FILV]xxxx[FILVW] 
1–12 [FILVW]xxxxxxxxxx[FILVW] 
1–14 [FILVW]xxxxxxxxxxxx[FILVW] 
1–8–14 [FILVW]xxxxxx[FAILVW]xxxxx[FILVW] 
1–5–8–14 [FILVW]xxx[FAILVW]xx[FAILVW]xxxxx[FILVW] 
Basic 1–8–14 [RK][RK][RK][FILVW]xxxxxx[FAILVW]xxxxx[FILVW] 
1–16 [FILVW]xxxxxxxxxxxxxx[FILVW] 
Ca2+ independent  
IQ [FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY] 
IQ-likea [FILV]Qxxx[RK]xxxxxxxx 
IQ-2A [IVL]QxxxRxxxx[VL][KR]xW 
IQ-2B [IL]QxxCxxxxKxRxW 
IQ unconventional [IVL]QxxxRxxxx[RK]xx[FILVWY] 
Motif Sequence 
Ca2+ dependent  
1–10 [FILVW]xxxxxxxx[FILVW] 
1–5–10 [FILVW]xxx[FAILVW]xxxx[FILVW] 
Basic 1–5–10 [RK][RK][RK][FAILVW]xxx[FILV]xxxx[FILVW] 
1–12 [FILVW]xxxxxxxxxx[FILVW] 
1–14 [FILVW]xxxxxxxxxxxx[FILVW] 
1–8–14 [FILVW]xxxxxx[FAILVW]xxxxx[FILVW] 
1–5–8–14 [FILVW]xxx[FAILVW]xx[FAILVW]xxxxx[FILVW] 
Basic 1–8–14 [RK][RK][RK][FILVW]xxxxxx[FAILVW]xxxxx[FILVW] 
1–16 [FILVW]xxxxxxxxxxxxxx[FILVW] 
Ca2+ independent  
IQ [FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY] 
IQ-likea [FILV]Qxxx[RK]xxxxxxxx 
IQ-2A [IVL]QxxxRxxxx[VL][KR]xW 
IQ-2B [IL]QxxCxxxxKxRxW 
IQ unconventional [IVL]QxxxRxxxx[RK]xx[FILVWY] 

Numbers for the Ca2+-dependent motifs indicate the positions that require a hydrophobic residue. Residues in the brackets can substitute for each other; x indicates any amino acid residue.

a

Some IQ-like motifs require Ca2+ for CaM binding.

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