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Table II.

Dwell time analysis of the wild-type single channel showing the effect of membrane stretch force on different states

[Ca2+Normalized dwell times of different states under 150-mmHg pressure (mean ± SD) No. of patches 
 C1 C2  
M 
10−5 0.21 ± 0.082 0.84 ± 0.24 1.3 ± 0.22 
10−6 0.13 ± 0.031 1.0 ± 0.59 1.9 ± 0.78 
[Ca2+Normalized dwell times of different states under 150-mmHg pressure (mean ± SD) No. of patches 
 C1 C2  
M 
10−5 0.21 ± 0.082 0.84 ± 0.24 1.3 ± 0.22 
10−6 0.13 ± 0.031 1.0 ± 0.59 1.9 ± 0.78 

Dwell times in different states under 150-mmHg pressure at two different [Ca2+] normalized to those without pressure (Fig. 2 B, top). Unity would indicate no change. As shown clearly, C1 is significantly reduced by pressure, whereas C2 and O are mildly affected. Note that the missed short C2 likely caused an overestimation of O.

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