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Table II.

V_1/2 and I_Ks current density at various potentials for WT and mutant KCNQ1 channels expressed with KCNE1

Variant	V_1/2	Current density (pA/pF)
	mV	0 mV	20 mV	at V_1/2	n	100 mV	n
WT	17.7 ± 2.4	92.1 ± 15.4	215.3 ± 25.4	215.3 ± 25.4	47	488.3 ± 52.8	25
D202H	34.3 ± 5.3	35.4 ± 7.0	88.9 ± 16.0	104.3 ± 18.6^a	24	311.7 ± 56.2	15
D202N	41.5 ± 2.9	9.4 ± 1.8	43.9 ± 9.3	98.6 ± 18.6^a	20	326.6 ± 59.7	14
I204F	71.0 ± 3.9	24.2 ± 11.4	49.8 ± 17.1	172.6 ± 32.8	22	424.1 ± 64.2	12
I204M	53.8 ± 2.6	21.2 ± 7.2	72.8 ± 16.3	157.9 ± 26.2	21	337.3 ± 46.1	16
V205M	37.0 ± 5.4	26.8 ± 4.4	78.4 ± 11.5	134.7 ± 17.8^a	38	344.6 ± 56.5	21
S209F	−31.0 ± 2.3	59.1 ± 9.1	75.7 ± 11.4	54.1 ± 8.3^a	25	121.4 ± 17.8^a	17
V215M	37.9 ± 4.3	18.8 ± 3.9	82.7 ± 20.0	172.0 ± 41.5	22	450.1 ± 84.8	17
V207M	24.8 ± 2.9	85.7 ± 17.6	200.1 ± 32.3	200.1 ± 32.3	20	486.9 ± 51.7	17

Variant	V_1/2	Current density (pA/pF)
	mV	0 mV	20 mV	at V_1/2	n	100 mV	n
WT	17.7 ± 2.4	92.1 ± 15.4	215.3 ± 25.4	215.3 ± 25.4	47	488.3 ± 52.8	25
D202H	34.3 ± 5.3	35.4 ± 7.0	88.9 ± 16.0	104.3 ± 18.6^a	24	311.7 ± 56.2	15
D202N	41.5 ± 2.9	9.4 ± 1.8	43.9 ± 9.3	98.6 ± 18.6^a	20	326.6 ± 59.7	14
I204F	71.0 ± 3.9	24.2 ± 11.4	49.8 ± 17.1	172.6 ± 32.8	22	424.1 ± 64.2	12
I204M	53.8 ± 2.6	21.2 ± 7.2	72.8 ± 16.3	157.9 ± 26.2	21	337.3 ± 46.1	16
V205M	37.0 ± 5.4	26.8 ± 4.4	78.4 ± 11.5	134.7 ± 17.8^a	38	344.6 ± 56.5	21
S209F	−31.0 ± 2.3	59.1 ± 9.1	75.7 ± 11.4	54.1 ± 8.3^a	25	121.4 ± 17.8^a	17
V215M	37.9 ± 4.3	18.8 ± 3.9	82.7 ± 20.0	172.0 ± 41.5	22	450.1 ± 84.8	17
V207M	24.8 ± 2.9	85.7 ± 17.6	200.1 ± 32.3	200.1 ± 32.3	20	486.9 ± 51.7	17

Current densities at V_1/2 for each mutant channel were corrected for difference in driving force from WT (see Materials and methods). Only current densities at V_1/2 and 100 mV were tested for significance.

P < 0.05 compared to WT.

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