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Table II.

V1/2 and IKs current density at various potentials for WT and mutant KCNQ1 channels expressed with KCNE1

Variant V1/2 Current density (pA/pF) 
 mV 0 mV 20 mV at V1/2 n 100 mV n 
WT 17.7 ± 2.4 92.1 ± 15.4 215.3 ± 25.4 215.3 ± 25.4 47 488.3 ± 52.8 25 
D202H 34.3 ± 5.3 35.4 ± 7.0 88.9 ± 16.0 104.3 ± 18.6a 24 311.7 ± 56.2 15 
D202N 41.5 ± 2.9 9.4 ± 1.8 43.9 ± 9.3 98.6 ± 18.6a 20 326.6 ± 59.7 14 
I204F 71.0 ± 3.9 24.2 ± 11.4 49.8 ± 17.1 172.6 ± 32.8 22 424.1 ± 64.2 12 
I204M 53.8 ± 2.6 21.2 ± 7.2 72.8 ± 16.3 157.9 ± 26.2 21 337.3 ± 46.1 16 
V205M 37.0 ± 5.4 26.8 ± 4.4 78.4 ± 11.5 134.7 ± 17.8a 38 344.6 ± 56.5 21 
S209F −31.0 ± 2.3 59.1 ± 9.1 75.7 ± 11.4 54.1 ± 8.3a 25 121.4 ± 17.8a 17 
V215M 37.9 ± 4.3 18.8 ± 3.9 82.7 ± 20.0 172.0 ± 41.5 22 450.1 ± 84.8 17 
V207M 24.8 ± 2.9 85.7 ± 17.6 200.1 ± 32.3 200.1 ± 32.3 20 486.9 ± 51.7 17 
Variant V1/2 Current density (pA/pF) 
 mV 0 mV 20 mV at V1/2 n 100 mV n 
WT 17.7 ± 2.4 92.1 ± 15.4 215.3 ± 25.4 215.3 ± 25.4 47 488.3 ± 52.8 25 
D202H 34.3 ± 5.3 35.4 ± 7.0 88.9 ± 16.0 104.3 ± 18.6a 24 311.7 ± 56.2 15 
D202N 41.5 ± 2.9 9.4 ± 1.8 43.9 ± 9.3 98.6 ± 18.6a 20 326.6 ± 59.7 14 
I204F 71.0 ± 3.9 24.2 ± 11.4 49.8 ± 17.1 172.6 ± 32.8 22 424.1 ± 64.2 12 
I204M 53.8 ± 2.6 21.2 ± 7.2 72.8 ± 16.3 157.9 ± 26.2 21 337.3 ± 46.1 16 
V205M 37.0 ± 5.4 26.8 ± 4.4 78.4 ± 11.5 134.7 ± 17.8a 38 344.6 ± 56.5 21 
S209F −31.0 ± 2.3 59.1 ± 9.1 75.7 ± 11.4 54.1 ± 8.3a 25 121.4 ± 17.8a 17 
V215M 37.9 ± 4.3 18.8 ± 3.9 82.7 ± 20.0 172.0 ± 41.5 22 450.1 ± 84.8 17 
V207M 24.8 ± 2.9 85.7 ± 17.6 200.1 ± 32.3 200.1 ± 32.3 20 486.9 ± 51.7 17 

Current densities at V1/2 for each mutant channel were corrected for difference in driving force from WT (see Materials and methods). Only current densities at V1/2 and 100 mV were tested for significance.

a

P < 0.05 compared to WT.

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