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Table III.

Peak current and NPopen measurements from the outside-out patch clamp experimentsa

Statistic α1β1γδL121C (control) (n = 8) α1β1γδL121C (n = 12) α1β1γL119CδL121C (n = 9) α1β1γδ (n = 8) 
Average post-/pre- NPopenb 0.44 (1) 0.28 (0.65) 0.060 (0.14) 0.36 (0.83) 
SEM 0.13 0.059 0.015 0.085 
Range 0.078–1.13 0.066–0.69 0.0088–0.11 0.14–0.65 
Median 0.38 0.25 0.066 0.36 
Average post-/pre- peakb 0.41 (1) 0.31 (0.74) 0.030 (0.073) 0.44 (1.06) 
SEM 0.081 0.084 0.0027 0.11 
Range 0.11–0.74 0.051–1.10 0.020–0.045 0.14–0.78 
Median 0.42 0.23 0.026 0.44 
Statistic α1β1γδL121C (control) (n = 8) α1β1γδL121C (n = 12) α1β1γL119CδL121C (n = 9) α1β1γδ (n = 8) 
Average post-/pre- NPopenb 0.44 (1) 0.28 (0.65) 0.060 (0.14) 0.36 (0.83) 
SEM 0.13 0.059 0.015 0.085 
Range 0.078–1.13 0.066–0.69 0.0088–0.11 0.14–0.65 
Median 0.38 0.25 0.066 0.36 
Average post-/pre- peakb 0.41 (1) 0.31 (0.74) 0.030 (0.073) 0.44 (1.06) 
SEM 0.081 0.084 0.0027 0.11 
Range 0.11–0.74 0.051–1.10 0.020–0.045 0.14–0.78 
Median 0.42 0.23 0.026 0.44 
a

1 mM ACh applied before and after 5-mM MTSEA treatment.

b

Normalized NPopen and peak values are indicated in parentheses.

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