Skip to Main Content
Table II.

MTSEA effects on muscle mutants expressed in Xenopus oocytes

Muscle mutant Before MTSEA After MTSEA 
 Imaxa EC50 Imaxa EC50 
  µM  µM 
α1β1γδL121C (n = 5) 1.30 ± 0.05 12.7 ± 1.5 1.41 ± 0.03 111 ± 8 
α1β1εL119Cδ (n = 3) 2.72 ± 0.08 48 ± 4 2.40 ± 0.02 126 ± 4 
α1β1εδL121C (n = 8) 2.56 ± 0.01 39.1 ± 0.4 1.84 ± 0.04 145 ± 9 
α1β1γδ wild-type (n = 5) 1.15 ± 0.03 4.52 ± 0.39 1.35 ± 0.05 3.24 ± 0.41 
α1β1εδ wild-type (n = 7) 1.28 ± 0.003 16.1 ± 0.10 1.53 ± 0.004 22.0 ± 0.11 
Muscle mutant Before MTSEA After MTSEA 
 Imaxa EC50 Imaxa EC50 
  µM  µM 
α1β1γδL121C (n = 5) 1.30 ± 0.05 12.7 ± 1.5 1.41 ± 0.03 111 ± 8 
α1β1εL119Cδ (n = 3) 2.72 ± 0.08 48 ± 4 2.40 ± 0.02 126 ± 4 
α1β1εδL121C (n = 8) 2.56 ± 0.01 39.1 ± 0.4 1.84 ± 0.04 145 ± 9 
α1β1γδ wild-type (n = 5) 1.15 ± 0.03 4.52 ± 0.39 1.35 ± 0.05 3.24 ± 0.41 
α1β1εδ wild-type (n = 7) 1.28 ± 0.003 16.1 ± 0.10 1.53 ± 0.004 22.0 ± 0.11 
a

Measured relative to average 30-µM ACh control before MTSEA treatment.

Close Modal

or Create an Account

Close Modal
Close Modal