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Table II.

MTSEA effects on muscle mutants expressed in Xenopus oocytes

Muscle mutant	Before MTSEA		After MTSEA
	I_max^a	EC₅₀	I_max^a	EC₅₀
		µM		µM
α1β1γδL121C (n = 5)	1.30 ± 0.05	12.7 ± 1.5	1.41 ± 0.03	111 ± 8
α1β1εL119Cδ (n = 3)	2.72 ± 0.08	48 ± 4	2.40 ± 0.02	126 ± 4
α1β1εδL121C (n = 8)	2.56 ± 0.01	39.1 ± 0.4	1.84 ± 0.04	145 ± 9
α1β1γδ wild-type (n = 5)	1.15 ± 0.03	4.52 ± 0.39	1.35 ± 0.05	3.24 ± 0.41
α1β1εδ wild-type (n = 7)	1.28 ± 0.003	16.1 ± 0.10	1.53 ± 0.004	22.0 ± 0.11

Muscle mutant	Before MTSEA		After MTSEA
	I_max^a	EC₅₀	I_max^a	EC₅₀
		µM		µM
α1β1γδL121C (n = 5)	1.30 ± 0.05	12.7 ± 1.5	1.41 ± 0.03	111 ± 8
α1β1εL119Cδ (n = 3)	2.72 ± 0.08	48 ± 4	2.40 ± 0.02	126 ± 4
α1β1εδL121C (n = 8)	2.56 ± 0.01	39.1 ± 0.4	1.84 ± 0.04	145 ± 9
α1β1γδ wild-type (n = 5)	1.15 ± 0.03	4.52 ± 0.39	1.35 ± 0.05	3.24 ± 0.41
α1β1εδ wild-type (n = 7)	1.28 ± 0.003	16.1 ± 0.10	1.53 ± 0.004	22.0 ± 0.11

Measured relative to average 30-µM ACh control before MTSEA treatment.