TABLE II.

Comparison of blocker impact on RIV for all HBE monolayers

Drug order Basal Forskolin GlyH-101 Forskolin+GlyH-101 Forskolin+Glibenclamide GlyH-101+Forskolin Glibenclamide+Forskolin 
wtHBE 1.06 ± 0.01 1.06 ± 0.02 0.97 ± 0.01 0.83 ± 0.03 1.39 ± 0.14 0.89 ± 0.01 1.50 ± 0.03 
GP adjusteda 1.17 ± 0.06  0.90 ± 0.05   0.66 ± 0.03  
Drug order Basal Forskolin GlyH-101 Forskolin+GlyH-101 Forskolin+Glibenclamide GlyH-101+Forskolin Glibenclamide+Forskolin 
wtHBE 1.06 ± 0.01 1.06 ± 0.02 0.97 ± 0.01 0.83 ± 0.03 1.39 ± 0.14 0.89 ± 0.01 1.50 ± 0.03 
GP adjusteda 1.17 ± 0.06  0.90 ± 0.05   0.66 ± 0.03  

Order of agonist or blocker represents experimental additions. Each measurement represents an n ≥ 6.

a

Values calculated with correction for paracellular conductance.

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