Rockefeller University Press

TABLE III

Activation Values

Channel	τ₊₂₀	n	τ₊₄₀	n	τ₊₆₀	n
Ctrl	95.6 ± 6.2	8	62.5 ± 3.7	8	49.9 ± 2.9	8
S654C	82.7 ± 2.7	7	52.9 ± 1.2^{^a}	6	46.9 ± 2.9	6
I655C	91.4 ± 1.9	11	61.1 ± 1.9	11	46.8 ± 2.1	11
F656C	110.5 ± 10.2	4	71.4 ± 6.6	4	65.6 ± 4.9^{^a}	4
G657C	30.4 ± 1.2^{^b}	13	24.7 ± 0.96^{^b}	13	22.4 ± 0.72^{^b}	13
N658C	46.29 ± 1.8^{^b}	5	35.1 ± 2.0^{^a}	5	28.8 ± 1.8^{^b}	5
V659C	84.6 ± 4.7	3	58.8 ± 3.4	3	50.6 ± 4.9	3
S660C	104.2 ± 4.7	5	69.9 ± 3.4	5	54.0 ± 2.5	5
A661C	299.2 ± 7.6^{^b}	10	169.1 ± 5.4^{^b}	10	114.8 ± 4.2^{^b}	10
I662C	41.2 ± 0.9^{^b}	12	29.3 ± 0.5^{^b}	12	22.6 ± 0.4^{^b}	12
I663C	277.7 ± 8.5^{^b}	10	159.8 ± 4.6^{^b}	10	110.5 ± 2.3^{^b}	10
Q664C	117.3 ± 13.0	7	68.2 ± 6.5	7	54.8 ± 4.2	8
R665C	66.9 ± 4.6^{^a}	6	40.7 ± 2.9^{^b}	6	32.3 ± 4.3^{^a}	5
L666C	94.1 ± 3.2	17	57.9 ± 1.8	17	42.4 ± 1.2^{^a}	17
Y667C	113.4 ± 4.5^{^b}	14	70.6 ± 2.4	14	54.3 ± 2.4	14
S688C	68.2 ± 2.9^{^b}	17	43.8 ± 2.3^{^b}	17	34.6 ± 2.0^{^b}	17

Channel	τ₊₂₀	n	τ₊₄₀	n	τ₊₆₀	n
Ctrl	95.6 ± 6.2	8	62.5 ± 3.7	8	49.9 ± 2.9	8
S654C	82.7 ± 2.7	7	52.9 ± 1.2^{^a}	6	46.9 ± 2.9	6
I655C	91.4 ± 1.9	11	61.1 ± 1.9	11	46.8 ± 2.1	11
F656C	110.5 ± 10.2	4	71.4 ± 6.6	4	65.6 ± 4.9^{^a}	4
G657C	30.4 ± 1.2^{^b}	13	24.7 ± 0.96^{^b}	13	22.4 ± 0.72^{^b}	13
N658C	46.29 ± 1.8^{^b}	5	35.1 ± 2.0^{^a}	5	28.8 ± 1.8^{^b}	5
V659C	84.6 ± 4.7	3	58.8 ± 3.4	3	50.6 ± 4.9	3
S660C	104.2 ± 4.7	5	69.9 ± 3.4	5	54.0 ± 2.5	5
A661C	299.2 ± 7.6^{^b}	10	169.1 ± 5.4^{^b}	10	114.8 ± 4.2^{^b}	10
I662C	41.2 ± 0.9^{^b}	12	29.3 ± 0.5^{^b}	12	22.6 ± 0.4^{^b}	12
I663C	277.7 ± 8.5^{^b}	10	159.8 ± 4.6^{^b}	10	110.5 ± 2.3^{^b}	10
Q664C	117.3 ± 13.0	7	68.2 ± 6.5	7	54.8 ± 4.2	8
R665C	66.9 ± 4.6^{^a}	6	40.7 ± 2.9^{^b}	6	32.3 ± 4.3^{^a}	5
L666C	94.1 ± 3.2	17	57.9 ± 1.8	17	42.4 ± 1.2^{^a}	17
Y667C	113.4 ± 4.5^{^b}	14	70.6 ± 2.4	14	54.3 ± 2.4	14
S688C	68.2 ± 2.9^{^b}	17	43.8 ± 2.3^{^b}	17	34.6 ± 2.0^{^b}	17

Values are derived from single exponential functions fit to activating current traces (see Materials and methods). Values are ± SEM.

P < 0.05.

P < 0.001.