Rockefeller University Press

TABLE I

Deactivation Values at −100 mV

Channel	τ_fast (ms)	τ_slow (ms)	τ_average (ms)	n
Ctrl	64.3 ± 3.1	254.7 ± 10.3	123.9 ± 6.1	9
S654C	84.4 ± 5.2^{^a}	486.5 ± 38.9^{^b}	285.5 ± 41.4^{^b}	6
I655C	139.4 ± 4.9^{^b}	734.5 ± 22.8^{^b}	504.8 ± 21.8^{^b}	10
F656C	71.8 ± 14.1	259.4 ± 60.1	107.2 ± 7.1	3
G657C	14.8 ± 1.3^{^b}	104.5 ± 12.9^{^b}	40.5 ± 4.3^{^b}	6
N658C	5.5 ± 0.03^{^b}	51.1 ± 2.9^{^a}	11.7 ± 1.5^{^b}	5
V659C	113.6 ± 6.4^{^b}	1,084.9 ± 40.7^{^b}	798.6 ± 62.9^{^b}	5
S660C	49.3 ± 3.6^{^a}	142.7 ± 8.7^{^b}	107.9 ± 2.5^{^b}	3
A661C	91.1 ± 6.5^{^a}	321.9 ± 24.7^{^b}	188.1 ± 15.3^{^b}	6
I662C	92.9 ± 2.7^{^a}	506.2 ± 75.1^{^b}	400.4 ± 70.2^{^b}	6
I663C	112.3 ± 5.4^{^b}	394.9 ± 15.5^{^b}	258.9 ± 13.7^{^b}	9
Q664C	106.6 ± 8.2^{^b}	1,044.4 ± 67.2^{^b}	764.9 ± 69.2^{^b}	6
R665C	81.8 ± 16.8	319.7 ± 71.8^{^b}	147.3 ± 16.8	4
L666C	71.8 ± 13.1	147.2 ± 4.7^{^b}	99.4 ± 8.0^{^a}	6
Y667C	138.7 ± 7.7^{^b}	802.9 ± 56.5^{^b}	627.03 ± 67.6^{^b}	8
S668C	197.9 ± 25.5^{^b}	1,809.7 ± 118.2^{^b}	1,489.3 ± 85.6^{^a}	13

Channel	τ_fast (ms)	τ_slow (ms)	τ_average (ms)	n
Ctrl	64.3 ± 3.1	254.7 ± 10.3	123.9 ± 6.1	9
S654C	84.4 ± 5.2^{^a}	486.5 ± 38.9^{^b}	285.5 ± 41.4^{^b}	6
I655C	139.4 ± 4.9^{^b}	734.5 ± 22.8^{^b}	504.8 ± 21.8^{^b}	10
F656C	71.8 ± 14.1	259.4 ± 60.1	107.2 ± 7.1	3
G657C	14.8 ± 1.3^{^b}	104.5 ± 12.9^{^b}	40.5 ± 4.3^{^b}	6
N658C	5.5 ± 0.03^{^b}	51.1 ± 2.9^{^a}	11.7 ± 1.5^{^b}	5
V659C	113.6 ± 6.4^{^b}	1,084.9 ± 40.7^{^b}	798.6 ± 62.9^{^b}	5
S660C	49.3 ± 3.6^{^a}	142.7 ± 8.7^{^b}	107.9 ± 2.5^{^b}	3
A661C	91.1 ± 6.5^{^a}	321.9 ± 24.7^{^b}	188.1 ± 15.3^{^b}	6
I662C	92.9 ± 2.7^{^a}	506.2 ± 75.1^{^b}	400.4 ± 70.2^{^b}	6
I663C	112.3 ± 5.4^{^b}	394.9 ± 15.5^{^b}	258.9 ± 13.7^{^b}	9
Q664C	106.6 ± 8.2^{^b}	1,044.4 ± 67.2^{^b}	764.9 ± 69.2^{^b}	6
R665C	81.8 ± 16.8	319.7 ± 71.8^{^b}	147.3 ± 16.8	4
L666C	71.8 ± 13.1	147.2 ± 4.7^{^b}	99.4 ± 8.0^{^a}	6
Y667C	138.7 ± 7.7^{^b}	802.9 ± 56.5^{^b}	627.03 ± 67.6^{^b}	8
S668C	197.9 ± 25.5^{^b}	1,809.7 ± 118.2^{^b}	1,489.3 ± 85.6^{^a}	13

Values reported were obtained by double exponential fits to deactivating current traces (see Materials and methods). Values are ± SEM.

P < 0.05.

P < 0.001.