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TABLE II

Rates of Ca2+ Clearance in Five Excitable Cell Types

Rate of [Ca2+]cyt fall (nM/s) @ 1000 nM Ca2+
Cell type
T (°C)
τ (s)
Total
SERCA
MtU
PMCA
NCX
PC12 cells (undiff.) 37 2.5 520 75 22 148 275 
PC12 cells (diff.) 37 2.7 420 67 −22 214 153 
Chromaffin cells 27 2–3 575 440 80 55 
SCG neurons 33 2.2 320 110 <40 80 120 
β-cells 35 1.7 500 290 105 105 
Sperm 21–23 45–55 1.5 4.9 1.6 
Rate of [Ca2+]cyt fall (nM/s) @ 1000 nM Ca2+
Cell type
T (°C)
τ (s)
Total
SERCA
MtU
PMCA
NCX
PC12 cells (undiff.) 37 2.5 520 75 22 148 275 
PC12 cells (diff.) 37 2.7 420 67 −22 214 153 
Chromaffin cells 27 2–3 575 440 80 55 
SCG neurons 33 2.2 320 110 <40 80 120 
β-cells 35 1.7 500 290 105 105 
Sperm 21–23 45–55 1.5 4.9 1.6 

Time constants of [Ca2+]cyt decay τ were obtained from exponential fits of Ca2+ clearance time courses. The rates of [Ca2+]cyt fall at 1000 nM Ca2+ were obtained from smoothed transport curves. Mitochondrial values from the present study are small and in the noise level. The results for mouse sperm (Wennemuth et al., 2003), rat pancreatic β cells (Chen et al., 2003), rat chromaffin cells (Herrington et al., 1996), and PC12 cells (this article) were collected in this laboratory. The results for rat superior cervical ganglion (SCG) neurons are from Wanaverbecq et al. (2003).

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