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TABLE IV

Comparison of Measured and Simulated Spatially Averaged Waveforms Elicited by one AP (16 °C)

1
2
3
4
5

peak
 amplitude
FDHM
 (ms)
peak
 amplitude
FDHM
 (ms)
A. Measurements     
    furaptra ΔfCaD 0.155 5.3 0.178 6.8 
    furaptra Δ[Ca2+17.5 μM 4.5 20.8 μM 6.0 
B. 18-Compartment simulations     
    furaptra ΔfCaD 0.155 5.1 0.178 7.3 
    Δ[Ca2+16.1 μM 3.6 19.1 μM 4.8 
    Ca2+ release flux 205 μM/ms 1.6 227 μM/ms 1.6 
    Δ[CaTotal349 μM – 386 μM – 
1
2
3
4
5

peak
 amplitude
FDHM
 (ms)
peak
 amplitude
FDHM
 (ms)
A. Measurements     
    furaptra ΔfCaD 0.155 5.3 0.178 6.8 
    furaptra Δ[Ca2+17.5 μM 4.5 20.8 μM 6.0 
B. 18-Compartment simulations     
    furaptra ΔfCaD 0.155 5.1 0.178 7.3 
    Δ[Ca2+16.1 μM 3.6 19.1 μM 4.8 
    Ca2+ release flux 205 μM/ms 1.6 227 μM/ms 1.6 
    Δ[CaTotal349 μM – 386 μM – 

The values in columns 2 and 3 were determined from the measurements and simulations in Fig. 3 (A and C); those in columns 4 and 5 were determined from the measurements and simulations in Fig. 10 in response to the conditioning AP. Δ[CaTotal] is the time integral of the release flux.

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