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TABLE I

Model Parameters for Spermine Block of Kir2.1 and D255 Mutant Channels


Rate


WT Kir2.1
D255A
D255R

O→B1 1.725 × 109 M−1s−1 4.99 × 107 M−1s−1 5.8 × 105 M−1s−1 0.23 
B1→O 1.03 × 105 s−1 4.50 × 104 s−1 2.82 × 104 s−1 0.19 
B1→B2 1.39 × 104 s−1 9.97 × 104 s−1 1.38 × 106 s−1 3.38 
B2→B1 2.77 × 102 s−1 2.55 × 102 s−1 54 s−1 1.39 
B2→O 3.9 s−1 0.30 s−1 0.45 s−1 0.01 

Rate


WT Kir2.1
D255A
D255R

O→B1 1.725 × 109 M−1s−1 4.99 × 107 M−1s−1 5.8 × 105 M−1s−1 0.23 
B1→O 1.03 × 105 s−1 4.50 × 104 s−1 2.82 × 104 s−1 0.19 
B1→B2 1.39 × 104 s−1 9.97 × 104 s−1 1.38 × 106 s−1 3.38 
B2→B1 2.77 × 102 s−1 2.55 × 102 s−1 54 s−1 1.39 
B2→O 3.9 s−1 0.30 s−1 0.45 s−1 0.01 
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