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TABLE I

Model Parameters for Spermine Block of Kir2.1 and D255 Mutant Channels

	Rate					zδ
	WT Kir2.1	D255A	D255R
O→B1	1.725 × 10⁹ M⁻¹s⁻¹	4.99 × 10⁷ M⁻¹s⁻¹	5.8 × 10⁵ M⁻¹s⁻¹	0.23
B1→O	1.03 × 10⁵ s⁻¹	4.50 × 10⁴ s⁻¹	2.82 × 10⁴ s⁻¹	0.19
B1→B2	1.39 × 10⁴ s⁻¹	9.97 × 10⁴ s⁻¹	1.38 × 10⁶ s⁻¹	3.38
B2→B1	2.77 × 10² s⁻¹	2.55 × 10² s⁻¹	54 s⁻¹	1.39
B2→O	3.9 s⁻¹	0.30 s⁻¹	0.45 s⁻¹	0.01

	Rate					zδ
	WT Kir2.1	D255A	D255R
O→B1	1.725 × 10⁹ M⁻¹s⁻¹	4.99 × 10⁷ M⁻¹s⁻¹	5.8 × 10⁵ M⁻¹s⁻¹	0.23
B1→O	1.03 × 10⁵ s⁻¹	4.50 × 10⁴ s⁻¹	2.82 × 10⁴ s⁻¹	0.19
B1→B2	1.39 × 10⁴ s⁻¹	9.97 × 10⁴ s⁻¹	1.38 × 10⁶ s⁻¹	3.38
B2→B1	2.77 × 10² s⁻¹	2.55 × 10² s⁻¹	54 s⁻¹	1.39
B2→O	3.9 s⁻¹	0.30 s⁻¹	0.45 s⁻¹	0.01