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TABLE I

Calculated Side Chain Transfer Free Energies

Residue	Water to DOPC  Interface (kJ/mol)	Water to Center of DOPC  Membrane (kJ/mol)
Leu	−14.1	−15.2
Ile	−20.6	−22.1
Val	−12.2	−13.8
Phe	−14.9	−12.8
Ala	−6.8	−8.4
Trp	−21.6	−4.9
Met	−10.5	−4.4
Cys	−6.6	−3.4
Tyr	−14.0	6.6
Thr	−4.2	13.9
Ser	−0.7	15.8
Gln	−8.9	20.2
Lys	−18.6^{^a}	19.9^{^b}
Asn	−6.5	23.9
Glu	−1.68^{^b}	21.1^{^b}
Asp	1.6^{^b}	31.0^{^b}
Arg	−21.2^{^a}	58.1^{^c}

Residue	Water to DOPC  Interface (kJ/mol)	Water to Center of DOPC  Membrane (kJ/mol)
Leu	−14.1	−15.2
Ile	−20.6	−22.1
Val	−12.2	−13.8
Phe	−14.9	−12.8
Ala	−6.8	−8.4
Trp	−21.6	−4.9
Met	−10.5	−4.4
Cys	−6.6	−3.4
Tyr	−14.0	6.6
Thr	−4.2	13.9
Ser	−0.7	15.8
Gln	−8.9	20.2
Lys	−18.6^{^a}	19.9^{^b}
Asn	−6.5	23.9
Glu	−1.68^{^b}	21.1^{^b}
Asp	1.6^{^b}	31.0^{^b}
Arg	−21.2^{^a}	58.1^{^c}

Residue is charged at this location.

Residue is neutral at this location.

Charged and neutral forms are equally likely.