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TABLE II

Relative Ca2+ and Cl Permeabilities Measured from Shifts in Erev

Protein
ΔErev,Ca
PCa/PCs
n
ΔErev,Cl
PCl/PCs
n
P2X1 9.3 ± 0.9 3.6 ± 0.2 −30.3 ± 1.1 0.09 ± 0.02 12 
P2X1-DM 3.9 ± 0.6 2.6 ± 0.1 −32.0 ± 1.2 0.07 ± 0.01 12 
P2X2 6.1 ± 0.4 2.9 ± 0.1  ND  
hP2X4 12.6 ± 1.6 4.6 ± 0.4 −29.7 ± 1.4 0.09 ± 0.02 
hP2X4-DM 4.5 ± 1.0 2.8 ± 0.1 −32.9 ± 1.1 0.06 ± 0.02 
hP2X5  ND  −5.8 ± 2.5 0.66 ± 0.12 
Protein
ΔErev,Ca
PCa/PCs
n
ΔErev,Cl
PCl/PCs
n
P2X1 9.3 ± 0.9 3.6 ± 0.2 −30.3 ± 1.1 0.09 ± 0.02 12 
P2X1-DM 3.9 ± 0.6 2.6 ± 0.1 −32.0 ± 1.2 0.07 ± 0.01 12 
P2X2 6.1 ± 0.4 2.9 ± 0.1  ND  
hP2X4 12.6 ± 1.6 4.6 ± 0.4 −29.7 ± 1.4 0.09 ± 0.02 
hP2X4-DM 4.5 ± 1.0 2.8 ± 0.1 −32.9 ± 1.1 0.06 ± 0.02 
hP2X5  ND  −5.8 ± 2.5 0.66 ± 0.12 

The control solution contained predominantly 150 mM CsCl, and the test solutions contained either 112 CaCl2 or 30 CsCl (see text for details). ΔErev,Ca = Erev,112 CaErev,150 CsCl. ΔErev,Cs = Erev,30 CsClErev,150,CsCl.

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