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TABLE I

Permeability Ratios of Various Anions in the WT CLC-0, K149L, and K149R Mutants






SCN

Cl

Br

NO3

I

F
WT (n = 3) Erev (mV) 7.1 ± 0.4 0.1 ± 0.0 −9.8 ± 0.3 −17.2 ± 0.6 −38.9 ± 1.1 −77.0 ± 3.5 
 PX/PCl 1.33 ± 0.02 – 0.68 ± 0.01 0.51 ± 0.01 0.22 ± 0.01 0.05 ± 0.01 
K149L (n = 4) Erev (mV) 20.6 ± 0.6 0.4 ± 0.1 −1.3 ± 0.1 −2.6 ± 0.1 −19.6 ± 2.4 −39.8 ± 2.9 
 PX/PCL 2.25 ± 0.05 – 0.95 ± 0.00 0.90 ± 0.01 0.47 ± 0.04 0.21 ± 0.02 
K149R (n = 4) Erev (mV) 11.5 ± 2.0 0.4 ± 0.2 −3.6 ± 0.7 −4.8 ± 0.6 −16.5 ± 1.9 −44.6 ± 2.6 

 
PX/PCl
 
1.59 ± 0.12
 

 
0.87 ± 0.02
 
0.83 ± 0.02
 
0.53 ± 0.04
 
0.18 ± 0.02
 





SCN

Cl

Br

NO3

I

F
WT (n = 3) Erev (mV) 7.1 ± 0.4 0.1 ± 0.0 −9.8 ± 0.3 −17.2 ± 0.6 −38.9 ± 1.1 −77.0 ± 3.5 
 PX/PCl 1.33 ± 0.02 – 0.68 ± 0.01 0.51 ± 0.01 0.22 ± 0.01 0.05 ± 0.01 
K149L (n = 4) Erev (mV) 20.6 ± 0.6 0.4 ± 0.1 −1.3 ± 0.1 −2.6 ± 0.1 −19.6 ± 2.4 −39.8 ± 2.9 
 PX/PCL 2.25 ± 0.05 – 0.95 ± 0.00 0.90 ± 0.01 0.47 ± 0.04 0.21 ± 0.02 
K149R (n = 4) Erev (mV) 11.5 ± 2.0 0.4 ± 0.2 −3.6 ± 0.7 −4.8 ± 0.6 −16.5 ± 1.9 −44.6 ± 2.6 

 
PX/PCl
 
1.59 ± 0.12
 

 
0.87 ± 0.02
 
0.83 ± 0.02
 
0.53 ± 0.04
 
0.18 ± 0.02
 
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