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Table I

Characteristics of the Currents Mediated by mKv1.7L and mKv1.7S Channels Expressed in Xenopus Oocytes Determined by TEVC Measurements


V1/2
Slope
RT75
τInac
V1/2Inac
SlopeInac
τRec1
τRec2
τCI
 2.5 mM K+
τCI
 117.5 mM K+
 mV  ms ms mV mV ms s s s 
mKv1.7L 4.4 ± 1.4 15.4 ± 0.5 4.4 ± 0.5 181.8 ± 15.4 −40 ± 0.7 mV 4 ± 0.3 1.2 ± 0.1 45.3 ± 4.5 8.1 ± 0.3 22.5 ± 4.4 
 n = 20 n = 20 n = 12 n = 15 n = 5 n = 5 n = 15 n = 15 n = 20 n = 23 
mKv1.7S −4.3 ± 2.9 13.3 ± 0.6 7.5 ± 0.7 643.2 ± 80.1 −21 ± 2 mV 7 ± 0.7 0.8 ± 0.1 34.6 ± 1.9 14.1 ± 4.8 38 ± 14.6 
 n = 15 n = 15 n = 12 n = 13 n = 5 n = 5 n = 9 n = 9 n = 6 n = 5 
 ** ns ** *** *** ** ** ns ** ** 

V1/2
Slope
RT75
τInac
V1/2Inac
SlopeInac
τRec1
τRec2
τCI
 2.5 mM K+
τCI
 117.5 mM K+
 mV  ms ms mV mV ms s s s 
mKv1.7L 4.4 ± 1.4 15.4 ± 0.5 4.4 ± 0.5 181.8 ± 15.4 −40 ± 0.7 mV 4 ± 0.3 1.2 ± 0.1 45.3 ± 4.5 8.1 ± 0.3 22.5 ± 4.4 
 n = 20 n = 20 n = 12 n = 15 n = 5 n = 5 n = 15 n = 15 n = 20 n = 23 
mKv1.7S −4.3 ± 2.9 13.3 ± 0.6 7.5 ± 0.7 643.2 ± 80.1 −21 ± 2 mV 7 ± 0.7 0.8 ± 0.1 34.6 ± 1.9 14.1 ± 4.8 38 ± 14.6 
 n = 15 n = 15 n = 12 n = 13 n = 5 n = 5 n = 9 n = 9 n = 6 n = 5 
 ** ns ** *** *** ** ** ns ** ** 

RT75 and τInac are at + 40 mV. τRec1 and τRec2 are the time constants for the recovery from inactivation. ns, not significant. *, P < 0.01; **, P < 0.001; ***, P = 0.0001.

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