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TABLE I

Effect of External Acidosis on Macroscopic Gating Kinetics of Homomeric KCNQ2 and KCNQ3 Currents



Activation (−30 mV)

Deactivation (−120 mV)

pH 7.4
pH 6.4
pH 7.4
pH 6.4
KCNQ2 405 ± 33 (9) 497 ± 37 (9)a 22.8 ± 0.4 (7) 34.8 ± 2.8 (7)b 
KCNQ3
 
235 ± 29 (7)
 
713 ± 43 (7)b
 
16.6 ± 0.7 (7)
 
22.2 ± 0.7 (7)b
 


Activation (−30 mV)

Deactivation (−120 mV)

pH 7.4
pH 6.4
pH 7.4
pH 6.4
KCNQ2 405 ± 33 (9) 497 ± 37 (9)a 22.8 ± 0.4 (7) 34.8 ± 2.8 (7)b 
KCNQ3
 
235 ± 29 (7)
 
713 ± 43 (7)b
 
16.6 ± 0.7 (7)
 
22.2 ± 0.7 (7)b
 
a

Significantly different to the corresponding value in pH 7.4 (P < 0.05; paired t test).

b

Significantly different to the corresponding value in pH 7.4 (P < 0.01; paired t test).

Values were obtained from the fit of single exponential functions to current relaxations. Activation relaxations were evoked by depolarizing pulses (3.0 s duration) from a holding potential of −70 mV. Deactivation relaxations were evoked by hyperpolarizing pulses (250 ms duration) after a prepulse to −30 mV (3.0 s duration). Values of n are shown in parentheses.

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