Skip to Main Content
TABLE I

Current Stability of Channels Formed by SUR1 and Kir6.2 Monomers


Mutation

Percentage current
 decay in 20 s

Inactivation
 time constanta τi

Number of
 patches (n)

 

 
s
 

 
WT 10.72 ± 3.66 N/A 10 
E229A 81.19 ± 5.39 6.64 ± 1.80 
R192A 78.24 ± 5.92 4.79 ± 1.34 
R301A >99.00 0.32 ± 0.03 
R314A 94.98 ± 1.89 3.08 ± 0.43 
E229R 92.94 ± 2.22 3.02 ± 0.31 
R192E 84.83 ± 1.10 5.19 ± 0.67 
R301E No currents N/A 16 
R314E 78.15 ± 3.44 1.28 ± 0.13 
E229R/R192E 66.06 ± 3.98 7.70 ± 0.06 11 
E229R/R301E No currents N/A 
E229R/R314E 6.95 ± 3.27 N/A 
E229C 75.14 ± 7.65 4.83 ± 0.96 
R314C No currents N/A 20 
E229C/R314C
 
46.98 ± 5.96
 
N/A
 
6
 

Mutation

Percentage current
 decay in 20 s

Inactivation
 time constanta τi

Number of
 patches (n)

 

 
s
 

 
WT 10.72 ± 3.66 N/A 10 
E229A 81.19 ± 5.39 6.64 ± 1.80 
R192A 78.24 ± 5.92 4.79 ± 1.34 
R301A >99.00 0.32 ± 0.03 
R314A 94.98 ± 1.89 3.08 ± 0.43 
E229R 92.94 ± 2.22 3.02 ± 0.31 
R192E 84.83 ± 1.10 5.19 ± 0.67 
R301E No currents N/A 16 
R314E 78.15 ± 3.44 1.28 ± 0.13 
E229R/R192E 66.06 ± 3.98 7.70 ± 0.06 11 
E229R/R301E No currents N/A 
E229R/R314E 6.95 ± 3.27 N/A 
E229C 75.14 ± 7.65 4.83 ± 0.96 
R314C No currents N/A 20 
E229C/R314C
 
46.98 ± 5.96
 
N/A
 
6
 
a

Values were given only for those mutants whose time course of inactivation could be fit well by a single exponential.

Close Modal

or Create an Account

Close Modal
Close Modal