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Table I.

Univariate and multivariate analyses of factors associated with survival and recurrence

 OS DFS 
 Univariate Multivariate Univariate Multivariate 
Variables p-value HR 95% CI p-value p-value HR 95% CI p-value 
Age, years (>48 vs. ≤48) 0.344   NA 0.643   NA 
Gender (female vs. male) 0.461   NA 0.215   NA 
HbsAg (positive vs. negative) 0.086   NA 0.127   NA 
Cirrhosis (present vs. absent) 0.211   NA 0.09   NA 
ALT, U/L (>42 vs. ≤42) 0.38   NA 0.883   NA 
AFP, ng/ml (>25 vs. ≤25) 0.005 1.68 1.07–2.62 0.023 0.221   NA 
Tumor size, cm (>5 vs. ≤5) 0.004 1.66 1.1–2.51 0.016 0.024 1.44 1–2.07 0.052 
Tumor multiplicity (multiple vs. solitary) <0.001 1.32 0.61–2.84 0.485 0.017 1.11 0.55–2.23 0.773 
Vascular invasion (present vs. absent) 0.002 2.1 1.19–3.74 0.011 0.006 1.88 1.1–3.23 0.022 
Intrahepatic metastasis (yes vs. no) <0.001 2.18 1.06–4.5 0.035 0.007 1.58 0.79–3.16 0.195 
TNM stage (III+IV vs. I+II) 0.014 0.68 0.37–1.26 0.219 0.034 0.96 0.56–1.63 0.869 
Tumor differentiation (III+IV vs. I+II) 0.1   NA 0.308   NA 
Fibrous capsule (present vs. absent) 0.263   NA 0.742   NA 
Peritumoral stroma Mϕ (high vs. low) <0.001 1.67 1.15–2.42 0.007 0.003 1.33 0.94–1.88 0.113 
 OS DFS 
 Univariate Multivariate Univariate Multivariate 
Variables p-value HR 95% CI p-value p-value HR 95% CI p-value 
Age, years (>48 vs. ≤48) 0.344   NA 0.643   NA 
Gender (female vs. male) 0.461   NA 0.215   NA 
HbsAg (positive vs. negative) 0.086   NA 0.127   NA 
Cirrhosis (present vs. absent) 0.211   NA 0.09   NA 
ALT, U/L (>42 vs. ≤42) 0.38   NA 0.883   NA 
AFP, ng/ml (>25 vs. ≤25) 0.005 1.68 1.07–2.62 0.023 0.221   NA 
Tumor size, cm (>5 vs. ≤5) 0.004 1.66 1.1–2.51 0.016 0.024 1.44 1–2.07 0.052 
Tumor multiplicity (multiple vs. solitary) <0.001 1.32 0.61–2.84 0.485 0.017 1.11 0.55–2.23 0.773 
Vascular invasion (present vs. absent) 0.002 2.1 1.19–3.74 0.011 0.006 1.88 1.1–3.23 0.022 
Intrahepatic metastasis (yes vs. no) <0.001 2.18 1.06–4.5 0.035 0.007 1.58 0.79–3.16 0.195 
TNM stage (III+IV vs. I+II) 0.014 0.68 0.37–1.26 0.219 0.034 0.96 0.56–1.63 0.869 
Tumor differentiation (III+IV vs. I+II) 0.1   NA 0.308   NA 
Fibrous capsule (present vs. absent) 0.263   NA 0.742   NA 
Peritumoral stroma Mϕ (high vs. low) <0.001 1.67 1.15–2.42 0.007 0.003 1.33 0.94–1.88 0.113 

Cox proportional hazards regression model. Variables used in multivariate analysis were adopted by univariate analysis. The underlined terms represent statistical significance. AFP, α-fetoprotein; ALT, alanine aminotransferase; CI, confidence interval; HbsAg, hepatitis B surface antigen; HR, hazard ratio; NA, not adopted; TNM, tumor node metastasis.

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