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Table I.

Distinct molecular features for organogenesis of different MALTs

Mice TALT NALT PP CLN MLN ILF Cryptopatch References 
Id2−/− +++ − − − − ND ND *1 
Rorγt−/− +++ +++ − − − − +/− *2 
Ltα−/− − − +/− − +/− *3 
aly/aly − − − − ++ *4 
Il-7rα−/− ++ ++ − +/− ++ ++ − *5 
Cxcl13−/− ++ +/− +/− ++ ND ND *6 
plt/plt +++ ++ ++ ++ ++ ND ND *7 
Cxcl13−/−plt/plt +/− − ++ ND ND *8 
Mice TALT NALT PP CLN MLN ILF Cryptopatch References 
Id2−/− +++ − − − − ND ND *1 
Rorγt−/− +++ +++ − − − − +/− *2 
Ltα−/− − − +/− − +/− *3 
aly/aly − − − − ++ *4 
Il-7rα−/− ++ ++ − +/− ++ ++ − *5 
Cxcl13−/− ++ +/− +/− ++ ND ND *6 
plt/plt +++ ++ ++ ++ ++ ND ND *7 
Cxcl13−/−plt/plt +/− − ++ ND ND *8 

CLN, cervical LN; MLN, mesenteric LN. +++, developed well; ++, developed with decreased number of lymphocytes; +, developed with few number of lymphocytes; −, absent; +/−, present or absent, depends on individual. *1, Yokota et al., 1999; Fukuyama et al., 2002; Boos et al., 2007; *2, Sun et al., 2000; Harmsen et al., 2002; Eberl and Littman, 2004; Eberl et al., 2004; Naito et al., 2008; Tsuji et al., 2008; *3, De Togni et al., 1994; Banks et al., 1995; Suzuki et al., 2000; Fukuyama et al., 2002; Hamada et al., 2002; Harmsen et al., 2002; Taylor et al., 2004; *4, Kanamori et al., 1996; Shinkura et al., 1999; Fukuyama et al., 2002; Hamada et al., 2002; *5, Peschon et al., 1994; Kanamori et al., 1996; Adachi et al., 1998b; Fukuyama et al., 2002; Hamada et al., 2002; Luther et al., 2003; *6, Ansel et al., 2000; Rangel-Moreno et al., 2005; Fukuyama et al., 2006; *7, Nakano et al., 1997; Rangel-Moreno et al., 2005; Fukuyama et al., 2006; and *8, Luther et al., 2003; Rangel-Moreno et al., 2005; Fukuyama et al., 2006.

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